TP53 stimulates APAF1 gene expression

Stable Identifier
R-HSA-6791348
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates APAF1 gene expression
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Once bound to the p53 response element in the promoter of the APAF1 gene, TP53 (p53) stimulates APAF1 transcription (Robles et al. 2001). APAF1 participates in the intrinsic apoptosis pathway, where its interaction with cytochrome C mediates the autocatalytic activation of pro-caspase-9 (Hu et al. 1999).
Literature References
PubMed ID Title Journal Year
11559530 APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

Bemmels, NA, Robles, AI, Harris, CC, Foraker, AB

Cancer Res. 2001
10393175 Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

Ding, L, Nunez, G, Benedict, MA, Hu, Y

EMBO J. 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:APAF1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-08-20)
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