Reactome | FTSJ3 [nucleoplasm]

FTSJ3 [nucleoplasm]

Stable Identifier

R-HSA-6791507

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="2"pre-rRNA processing protein FTSJ3 ecNumber evidence="2"2.1.1.-/ecNumber, SPB1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
22195017	The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing Zanchin, NI, Nickerson, JA, Singh, G, Silva, TC, Coltri, PP, Quaresma, AJ, Moore, MJ, Morello, LG, Oliveira, CC, Simabuco, FM	PLoS ONE	2011

External Reference Information

External Reference

UniProt:Q8IY81 FTSJ3

Gene Names

FTSJ3, SB92

Chain

chain:1-847

Reference Genes

BioGPS Gene:117246 FTSJ3

COSMIC (genes):FTSJ3 FTSJ3

CTD Gene:117246 FTSJ3

dbSNP Gene:117246 FTSJ3

ENSEMBL:ENSG00000108592 FTSJ3

HGNC:17136 FTSJ3

KEGG:hsa:117246 FTSJ3

Monarch:117246 FTSJ3

NCBI Gene:117246 FTSJ3

OMIM:618411 FTSJ3

UCSC:Q8IY81 FTSJ3

Reference Transcript

RefSeq:NM_017647.3 FTSJ3

Other Identifiers

11719034_a_at

117246

11750693_a_at

16847621

218103_PM_at

218103_at

3766374

3766375

3766376

3766377

3766378

3766379

3766380

3766381

3766382

3766383

3766384

3766385

3766386

3766387

3766388

3766390

3766391

3766392

3766393

3766394

3766395

3766396

3766397

3766398

3766399

3766400

3766401

3766402

3766403

3766404

3766405

3766406

3766407

3766408

3766409

3766410

43464_at

8017437

A_23_P55091

GE82194

GE85125

GO:0000463

GO:0000466

GO:0001510

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006364

GO:0008168

GO:0008649

GO:0008650

GO:0016435

GO:0016740

GO:0030687

GO:0030688

GO:0031167

GO:0032259

GO:0042254

GO:0043226

GO:0062105

GO:0140098

HMNXSV003041175

ILMN_1811692

PH_hs_0013527

TC17001786.hg

g8923066_3p_at

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Inferred To

FTSJ3 [nucleoplasm] (Bos taurus)

FTSJ3 [nucleoplasm] (Canis familiaris)

FTSJ3 [nucleoplasm] (Mus musculus)

FTSJ3 [nucleoplasm] (Rattus norvegicus)

FTSJ3 [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000108592

ENSEMBL

ENST00000427159, ENSG00000108592, ENSP00000396673

GeneCards

FTSJ3

HPA

ENSG00000108592-FTSJ3

PRO

Q8IY81

Pharos - Targets

Q8IY81

GlyGen

Q8IY81

HMDB Protein

HMDBP09032

PDB

8FKT, 8FKR, 8FKY, 8FKQ, 8FKS, 8IR1, 8FKV, 8FKP, 8FKX, 8FKU, 8FKW

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.669	4
UniProt:Q9UPE1 SRPK3			0.643	3
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332)	0.623	3
UniProt:Q9Y3U8 RPL36	1	RPL36 [cytosol] (R-HSA-72464)	0.564	2
UniProt:P16403 H1-2	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.564	2
UniProt:Q16385-2 Q163852			0.556	3
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	3
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	3
UniProt:Q96HE9 PRR11			0.527	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	3
UniProt:Q9NQZ8 ZNF71	1	ZNF71 [nucleoplasm] (R-HSA-2454145)	0.527	3
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:Q9H6Y2 WDR55			0.527	2
UniProt:P10074 TZAP			0.527	2
UniProt:Q15397 PUM3			0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:Q53GL0 PKHO1			0.527	2
UniProt:Q9BXY0 MAK16			0.527	2
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.527	3
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	3
UniProt:Q9NZM5 NOP53			0.527	3
UniProt:Q15020 SART3			0.527	3
UniProt:P42696 RBM34			0.527	3
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:Q9Y6K5 OAS3	1	OAS3 [cytosol] (R-HSA-1015672)	0.499	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	3
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.462	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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