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C1D [nucleoplasm]
Stable Identifier
R-HSA-6791515
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear nucleic acid-binding protein C1D, C1D_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nuclear RNA decay (Homo sapiens)
MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosome [nucleoplasm] (Homo sapiens)
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
C1D [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13901 C1D
Gene Names
C1D
Chain
chain:1-141
Reference Genes
BioGPS Gene:10438 C1D
COSMIC (genes):C1D C1D
CTD Gene:10438 C1D
dbSNP Gene:10438 C1D
ENSEMBL:ENSG00000197223 C1D
HGNC:29911 C1D
KEGG:hsa:10438 C1D
Monarch:10438 C1D
NCBI Gene:10438 C1D
OMIM:606997 C1D
UCSC:Q13901 C1D
Reference Transcript
RefSeq:NM_006333.4 C1D
RefSeq:NM_001190263.2 C1D
RefSeq:NM_173177.3 C1D
RefSeq:NM_001190265.2 C1D
Other Identifiers
10438
11718174_x_at
11748703_a_at
11748704_s_at
16655921
16655923
16655925
16655927
16655929
16655931
16655933
16655935
16655947
16898485
18670323
18670324
18670325
18670326
18670327
18670328
18670329
18670330
18670331
18670332
200056_PM_s_at
200056_s_at
2557558
2557559
2557560
2557561
2557562
2557563
2557564
2557565
2557566
2557567
2557568
2557569
2557570
2557571
2557572
2557573
2557574
2557575
2557577
2557578
2557583
2557611
2557613
2557615
2557617
2557619
2557621
2557623
2557625
2557627
2557653
3284162
3284163
3284164
3284165
3284166
3297355
3297356
3297357
3297359
3297484
3297490
39782_at
7892554
7892591
7893702
7893795
7893913
7893918
7894014
7894326
7894355
7894785
7894827
7895083
7895153
7895479
7895876
7896317
7932964
7934729
7934731
8052698
80643_at
A_23_P56590
A_23_P67992
GE561176
GE60176
GO:0000176
GO:0000178
GO:0000460
GO:0003677
GO:0003714
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006355
GO:0006364
GO:0006915
GO:0010468
GO:0016922
GO:0017053
GO:0045892
HMNXSV003007741
ILMN_1762330
ILMN_2394613
TC02001938.hg
X95592_at
g5453582_3p_a_at
Participates
as a component of
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
(Homo sapiens)
Other forms of this molecule
C1D [nucleolus]
Inferred To
C1d [nucleoplasm]
(Mus musculus)
C1d [nucleoplasm]
(Rattus norvegicus)
Rrp47 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of C1D [nucleoplasm]
(Dictyostelium discoideum)
C1D [nucleoplasm]
(Bos taurus)
C1D [nucleoplasm]
(Caenorhabditis elegans)
C1D [nucleoplasm]
(Canis familiaris)
C1D [nucleoplasm]
(Gallus gallus)
C1D [nucleoplasm]
(Schizosaccharomyces pombe)
C1D [nucleoplasm]
(Sus scrofa)
LRP1 [nucleoplasm]
(Saccharomyces cerevisiae)
c1d [nucleoplasm]
(Danio rerio)
c1d [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001177192.1
,
NP_001177194.1
,
NP_775269.1
,
NP_006324.1
OpenTargets
ENSG00000197223
ENSEMBL
ENST00000409302
,
ENSG00000197223
,
ENST00000410067
,
ENSP00000386468
,
ENSP00000348107
,
ENSP00000386779
,
ENST00000355848
GeneCards
C1D
HPA
ENSG00000197223-C1D
PRO
Q13901
Pharos - Targets
Q13901
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5
3
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
EXOSC5 [nucleolus]
(R-HSA-9935829)
0.788
6
UniProt:Q99547 MPHOSPH6
2
MPHOSPH6 [nucleolus]
(R-HSA-9935781)
MPHOSPH6 [nucleoplasm]
(R-HSA-6791553)
0.744
6
UniProt:Q01780 EXOSC10
2
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
EXOSC10 [nucleolus]
(R-HSA-9935809)
0.733
7
UniProt:Q9Y371 SHLB1
0.718
6
UniProt:Q13868 EXOSC2
3
EXOSC2 [cytosol]
(R-HSA-429999)
EXOSC2 [nucleoplasm]
(R-HSA-6791582)
EXOSC2 [nucleolus]
(R-HSA-9935794)
0.643
4
UniProt:Q9Y3B2 EXOSC1
3
EXOSC1 [cytosol]
(R-HSA-429841)
EXOSC1 [nucleoplasm]
(R-HSA-6791578)
EXOSC1 [nucleolus]
(R-HSA-9935836)
0.643
5
UniProt:Q9NPD3 EXOSC4
3
EXOSC4 [nucleolus]
(R-HSA-9935803)
EXOSC4 [nucleoplasm]
(R-HSA-6791503)
EXOSC4 [cytosol]
(R-HSA-430013)
0.643
4
UniProt:O60293 ZFC3H1
1
ZFC3H1 [nucleoplasm]
(R-HSA-9930046)
0.643
3
UniProt:O00291 HIP1
7
HIP1 [cytosol]
(R-HSA-8868153)
HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol]
(R-HSA-9711952)
HIP1(1-1019)-ALK(1058-1620) [cytosol]
(R-HSA-9711970)
HIP1(1-963)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711972)
HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9711965)
HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol]
(R-HSA-9711956)
HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711975)
0.556
3
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:O15499 GSC2
0.556
3
UniProt:Q5VWK5 IL23R
2
IL23R [plasma membrane]
(R-HSA-447156)
p-Y-IL23R [plasma membrane]
(R-HSA-8950616)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P13473-2 P134732
0.556
3
UniProt:P62826 RAN
2
RAN [nucleoplasm]
(R-HSA-165528)
RAN [cytosol]
(R-HSA-165540)
0.556
3
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.556
3
UniProt:Q8N5A5-2 ZGPAT
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q15024 EXOSC7
3
EXOSC7 [nucleolus]
(R-HSA-9935779)
EXOSC7 [nucleoplasm]
(R-HSA-6791543)
EXOSC7 [cytosol]
(R-HSA-430030)
0.527
3
UniProt:Q9NQT5 EXOSC3
3
EXOSC3 [cytosol]
(R-HSA-430017)
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
EXOSC3 [nucleolus]
(R-HSA-9935842)
0.527
3
UniProt:Q9H8H0 NOL11
1
NOL11 [nucleoplasm]
(R-HSA-6790684)
0.527
2
UniProt:Q9Y2L1 DIS3
3
DIS3 [nucleolus]
(R-HSA-9935841)
DIS3 [nucleoplasm]
(R-HSA-6791517)
DIS3 [cytosol]
(R-HSA-429935)
0.527
3
UniProt:Q06265 EXOSC9
3
EXOSC9 [nucleolus]
(R-HSA-9935807)
EXOSC9 [nucleoplasm]
(R-HSA-6791577)
EXOSC9 [cytosol]
(R-HSA-429984)
0.527
2
UniProt:Q8TED0 UTP15
1
UTP15 [nucleoplasm]
(R-HSA-6790678)
0.527
2
UniProt:P42285 MTREX
2
SKIV2L2 [nucleoplasm]
(R-HSA-6791189)
MTREX [nucleolus]
(R-HSA-9935826)
0.527
3
UniProt:Q9Y580 RBM7
1
RBM7 [nucleoplasm]
(R-HSA-8985564)
0.527
3
UniProt:Q6NZY4 ZCCHC8
1
ZCCHC8 [nucleoplasm]
(R-HSA-8985573)
0.527
3
UniProt:Q96B26 EXOSC8
3
EXOSC8 [cytosol]
(R-HSA-429912)
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [nucleolus]
(R-HSA-9935805)
0.527
3
UniProt:Q15061 WDR43
1
WDR43 [nucleoplasm]
(R-HSA-6790653)
0.527
2
UniProt:Q5RKV6 EXOSC6
3
EXOSC6 [nucleolus]
(R-HSA-9935802)
EXOSC6 [nucleoplasm]
(R-HSA-6791573)
EXOSC6 [cytosol]
(R-HSA-429921)
0.527
3
UniProt:Q8IWA0 WDR75
1
WDR75 [nucleoplasm]
(R-HSA-6790666)
0.527
2
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