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DIS3 [nucleoplasm]
Stable Identifier
R-HSA-6791517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Exosome complex exonuclease RRP44 ecNumber3.1.13.-/ecNumber ecNumber3.1.26.-/ecNumber, RRP44_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q01780 EXOSC10
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
DIS3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2L1 DIS3
Gene Names
DIS3, KIAA1008, RRP44
Chain
chain:1-958
Reference Genes
BioGPS Gene:22894 DIS3
COSMIC (genes):DIS3 DIS3
CTD Gene:22894 DIS3
dbSNP Gene:22894 DIS3
ENSEMBL:ENSG00000083520 DIS3
ENSEMBL_homo_sapiens_GENE:ENSG00000083520.15 DIS3
HGNC:20604 DIS3
KEGG Gene (Homo sapiens):22894 DIS3
Monarch:22894 DIS3
NCBI Gene:22894 DIS3
OMIM:607533 DIS3
UCSC:Q9Y2L1 DIS3
Reference Transcript
RefSeq:NM_014953.4 DIS3
RefSeq:NM_001128226.2 DIS3
Other Identifiers
11726622_a_at
11726623_a_at
11748232_a_at
16779725
214194_PM_at
214194_at
218362_3p_s_at
218362_PM_s_at
218362_s_at
222607_PM_s_at
222607_s_at
22894
234660_PM_s_at
234660_s_at
234757_PM_at
234757_at
236560_PM_at
236560_at
3517586
3517588
3517590
3517592
3517593
3517595
3517596
3517597
3517598
3517599
3517600
3517601
3517602
3517603
3517604
3517605
3517606
3517608
3517610
3517611
3517613
3517616
3517617
3517618
3517619
3517620
3517621
3517622
3517623
3517624
3517625
3517626
3517627
3517628
3517629
3517630
3517633
3517634
3517635
3517636
40633_at
7971965
7971967
84273_at
A_23_P412613
A_23_P48416
A_24_P219024
A_24_P395317
A_32_P205522
A_33_P3395502
GE53651
GO:0000175
GO:0000176
GO:0000177
GO:0000178
GO:0003723
GO:0003824
GO:0004518
GO:0004519
GO:0004527
GO:0004540
GO:0005085
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006364
GO:0006396
GO:0006401
GO:0016020
GO:0016071
GO:0016075
GO:0016787
GO:0042254
GO:0043226
GO:0043928
GO:0071034
GO:0098772
GO:0140098
HMNXSV003013894
HMNXSV003020865
Hs.179566.0.S1_3p_at
Hs.323346.0.S1_3p_a_at
Hs.323346.1.S1_3p_a_at
Hs.326725.0.A1_3p_at
Hs.59661.0.S1_3p_at
ILMN_1799796
PH_hs_0016095
TC13000727.hg
TC13001569.hg
U79246_at
g7662443_3p_x_at
This entity regulates
Positively
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
(Homo sapiens)
Other forms of this molecule
DIS3 [cytosol]
Inferred To
dis3 [nucleoplasm]
(Schizosaccharomyces pombe)
dis3 [nucleoplasm]
(Xenopus tropicalis)
dis-3 [nucleoplasm]
(Caenorhabditis elegans)
Dis3 [nucleoplasm]
(Drosophila melanogaster)
Dis3 [nucleoplasm]
(Mus musculus)
Dis3 [nucleoplasm]
(Rattus norvegicus)
DIS3 [nucleoplasm]
(Bos taurus)
DIS3 [nucleoplasm]
(Canis familiaris)
DIS3 [nucleoplasm]
(Saccharomyces cerevisiae)
DIS3 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001121698.1
,
NP_055768.3
OpenTargets
ENSG00000083520
HPA
ENSG00000083520-DIS3
GeneCards
Q9Y2L1
Ensembl
ENST00000377767
,
ENSP00000367011
,
ENST00000377780
,
ENSG00000083520
,
ENSP00000366997
PRO
Q9Y2L1
Pharos - Targets
Q9Y2L1
PDB
6H25
,
6D6R
,
6D6Q
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQT5 EXOSC3
2
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
EXOSC3 [cytosol]
(R-HSA-430017)
0.744
4
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.738
4
UniProt:Q13868 EXOSC2
2
EXOSC2 [nucleoplasm]
(R-HSA-6791582)
EXOSC2 [cytosol]
(R-HSA-429999)
0.623
3
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.547
2
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.527
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q96NY9 MUS81
1
MUS81 [nucleoplasm]
(R-HSA-5686443)
0.527
3
UniProt:P02675 FGB
5
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [extracellular region]
(R-HSA-140584)
0.527
2
UniProt:P05120 SERPINB2
2
SERPINB2 [plasma membrane]
(R-HSA-159004)
SERPINB2 [extracellular region]
(R-HSA-158997)
0.527
2
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:Q9NPD3 EXOSC4
2
EXOSC4 [nucleoplasm]
(R-HSA-6791503)
EXOSC4 [cytosol]
(R-HSA-430013)
0.462
2
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