Reactome | BYSL [cytosol]

BYSL [cytosol]

Stable Identifier

R-HSA-6791518

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Bystin, BYST_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y2P0 ZN835

Expand all

External Reference Information

External Reference

UniProt:Q13895 BYSL

Gene Names

BYSL, ENP1

Chain

chain:1-437

Reference Genes

BioGPS Gene:705 BYSL

COSMIC (genes):BYSL BYSL

CTD Gene:705 BYSL

dbSNP Gene:705 BYSL

ENSEMBL:ENSG00000112578 BYSL

ENSEMBL_homo_sapiens_GENE:ENSG00000112578.10 BYSL

HGNC:1157 BYSL

KEGG Gene (Homo sapiens):705 BYSL

Monarch:705 BYSL

NCBI Gene:705 BYSL

OMIM:603871 BYSL

UCSC:Q13895 BYSL

Reference Transcript

RefSeq:NM_004053.3 BYSL

Other Identifiers

11717444_at

17008544

203612_PM_at

203612_at

2906992

2906994

2906995

2906996

2906997

2906998

2906999

2907000

2907001

41415_at

705

8119492

A_14_P116467

A_23_P145197

GE57741

GO:0000462

GO:0001701

GO:0001825

GO:0001829

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0016020

GO:0030154

GO:0030515

GO:0030688

GO:0042254

GO:0043226

GO:0043229

GO:0043231

GO:0045177

GO:0048856

GO:0072089

GO:1904749

HMNXSV003029839

ILMN_1682792

L36720_at

PH_hs_0005945

TC06000577.hg

g4757881_3p_at

Participates

as an output of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

Other forms of this molecule

BYSL [nucleoplasm]

Inferred To

bysl [cytosol] (Danio rerio)

bysl [cytosol] (Xenopus tropicalis)

Bysl [cytosol] (Mus musculus)

Bysl [cytosol] (Rattus norvegicus)

byn-1 [cytosol] (Caenorhabditis elegans)

BYSL [cytosol] (Bos taurus)

BYSL [cytosol] (Canis familiaris)

BYSL [cytosol] (Gallus gallus)

BYSL [cytosol] (Sus scrofa)

bys [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_004044.3

OpenTargets

ENSG00000112578

GeneCards

Q13895

HPA

ENSG00000112578-BYSL

Ensembl

ENSG00000112578, ENSP00000230340, ENST00000230340

PRO

Q13895

Pharos - Targets

Q13895

PDB

6G18, 7WU0, 7WTZ, 6G4W, 7WTW, 7WTX, 6G4S, 7WTV, 7WTT, 7WTU

Interactors (174)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.871	15
UniProt:P38432 COIL			0.841	11
UniProt:Q96HT8 MR1L1			0.841	13
UniProt:Q9BUZ4 TRAF4			0.781	9
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.781	9
UniProt:Q9UL42 PNMA2			0.781	7
UniProt:Q6NT76 HMBX1			0.718	8
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.718	8
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.718	8
UniProt:Q68D86 C102B			0.718	6
UniProt:Q96BR9 ZBT8A			0.718	8
UniProt:O75558 STX11			0.718	8
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:P51116 FXR2			0.718	8
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.718	8
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.718	8
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.718	8
UniProt:Q9UJV3-2 MID2			0.718	8
UniProt:Q9NVV9 THAP1			0.718	8
UniProt:O43829 ZBT14			0.718	8
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.718	6
UniProt:Q8N7W2-2 BEND7			0.718	8
UniProt:Q7Z6G3-2 NECAB2			0.718	6
UniProt:Q8TD10 MIPO1			0.718	8
UniProt:Q9BYV2 TRI54			0.718	7
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.718	8
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	8
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.718	6
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.706	4
UniProt:Q08117-2 TLE5			0.696	5
UniProt:Q96IK5 GMCL1			0.696	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.696	5
UniProt:Q15654 TRIP6			0.666	6
UniProt:Q969V4 TEKT1			0.666	6
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.666	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.666	5
UniProt:O95751 LDOC1			0.666	4
UniProt:Q9BVG8-5 KIFC3			0.666	5
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.666	6
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.643	4
UniProt:Q5JTH9 RRP12			0.643	4
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.643	4
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.643	5
UniProt:O95453 PARN	1	PARN [cytosol] (R-HSA-430009)	0.643	4
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.643	3
UniProt:Q12815 TROAP			0.598	9
UniProt:Q15303 ERBB4			0.577	3
UniProt:Q86SE5 RALYL			0.556	3
UniProt:Q9NWS0 PIHD1			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:P20807-4 CAPN3			0.556	3
UniProt:Q9BW62 KATL1			0.556	3
UniProt:Q9NYW8 RBAK			0.556	3
UniProt:P25791-3 LMO2			0.556	3
UniProt:Q9C0F1 CEP44			0.556	5
UniProt:A4D1L5 A4D1L5			0.556	3
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:O75564-2 O755642			0.556	3
UniProt:Q9UBR4-2 LHX3			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	5
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
IntAct:EBI-10171679 386682			0.556	5
UniProt:Q5VU43 MYOME			0.556	5
UniProt:Q96K58-2 ZNF668			0.556	3
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.556	3
UniProt:Q8IYB1 M21D2			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	5
UniProt:Q96MX3 ZNF48			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	5
UniProt:A0A0C3SFZ9 A0A0C3SFZ9			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.556	3
UniProt:Q8NCY6 MSD4			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9BYV6-2 TRIM55			0.556	3
UniProt:Q9HBT8 ZNF286A	1	ZNF286A [nucleoplasm] (R-HSA-1027429)	0.556	3
UniProt:Q13422 IKZF1			0.556	5
UniProt:Q86T90 K1328			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q92622 RUBIC			0.556	3
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q9UDW3 ZMAT5	1	ZMAT5 [nucleoplasm] (R-HSA-6787850)	0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:Q86W67 F228A			0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.556	3
UniProt:O14958 CASQ2	1	CASQ2 [sarcoplasmic reticulum membrane] (R-HSA-2855225)	0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	5
IntAct:EBI-23219619 CCSB ORF ID			0.556	3
UniProt:Q5BKX8 CAVN4			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q5JR59 MTUS2			0.556	5
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q5VU43-2 PDE4DIP			0.556	3
UniProt:Q53GL6 Q53GL6			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q9Y2P0 ZN835			0.556	3
UniProt:Q8TA86 RP9			0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
IntAct:EBI-10171584 80125			0.556	5
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q9UPY6-2 WASF3			0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.556	3
UniProt:Q96GN5 CDA7L			0.556	5
UniProt:Q9P0T4 ZN581			0.556	3
UniProt:Q8NF50-2 DOCK8			0.556	5
UniProt:P35240-4 NF2			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q9UDV6 ZNF212	1	ZNF212 [nucleoplasm] (R-HSA-1027348)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.556	3
UniProt:Q96JM7 LMBL3			0.556	5
UniProt:Q8WZ60 KLHL6			0.556	3
UniProt:Q495M9 USH1G	1	USH1G [cytosol] (R-HSA-9658869)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q9H4L5 OSBPL3	1	OSBPL3 [cytosol] (R-HSA-8867532)	0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q9HAF1 MEAF6	1	MEAF6 [nucleoplasm] (R-HSA-3318448)	0.556	3
UniProt:Q4V328 GRAP1			0.556	3
UniProt:Q15007 WTAP	1	WTAP [nucleoplasm] (R-HSA-6789461)	0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q9NTW7 ZF64B			0.556	5
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.556	3
UniProt:Q9NP66 HM20A			0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	5
UniProt:D6RGH6 MCIN			0.556	3
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.556	5
UniProt:Q12934-2 BFSP1			0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	5
UniProt:P10073 ZSC22			0.556	3
UniProt:Q9Y2D8 ADIP			0.556	5
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	5
UniProt:Q9UHC7 MKRN1	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.556	3
UniProt:O95198 KLHL2	1	KLHL2 [cytosol] (R-HSA-8863217)	0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	5
UniProt:Q56P03 EAPP			0.556	3
UniProt:Q7RTU3 OLIG3			0.556	5
UniProt:Q9NQZ8 ZNF71	1	ZNF71 [nucleoplasm] (R-HSA-2454145)	0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:Q96MT3 PRICKLE1	2	PRICKLE1 [cytosol] (R-HSA-4608816) ub-PRICKLE1 [cytosol] (R-HSA-4608820)	0.556	3
UniProt:P39019 RPS19	2	RPS19 [nucleoplasm] (R-HSA-6798710) RPS19 [cytosol] (R-HSA-72343)	0.527	2
UniProt:Q9NSI2 SLX9			0.527	4
UniProt:Q9Y4C8 RBM19			0.527	2
UniProt:P48730 CSNK1D	3	CSNK1D [nucleoplasm] (R-HSA-421305) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717) CSNK1D [cytosol] (R-HSA-380315)	0.527	2
UniProt:Q9BVS4 RIOK2	2	RIOK2 [nucleoplasm] (R-HSA-6791569) RIOK2 [cytosol] (R-HSA-6791533)	0.527	3
UniProt:P49366 DHPS	1	DHPS [cytosol] (R-HSA-204630)	0.527	3
UniProt:Q86U38 NOP9			0.527	2
UniProt:Q13206 DDX10			0.527	2
UniProt:Q8NEF9 SRFB1			0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.488	2
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.483	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2
UniProt:Q12816 TROP			0.462	4

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