Reactome | RIOK1 [cytosol]

RIOK1 [cytosol]

Stable Identifier

R-HSA-6791525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase RIO1 ecNumber2.7.11.1/ecNumber, RIOK1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NY12 GAR1

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External Reference Information

External Reference

UniProt:Q9BRS2 RIOK1

Gene Names

RIOK1, RIO1

Chain

chain:1-568

Reference Genes

BioGPS Gene:83732 RIOK1

COSMIC (genes):RIOK1 RIOK1

CTD Gene:83732 RIOK1

dbSNP Gene:83732 RIOK1

ENSEMBL:ENSG00000124784 RIOK1

HGNC:18656 RIOK1

Monarch:83732 RIOK1

NCBI Gene:83732 RIOK1

OMIM:617753 RIOK1

UCSC:Q9BRS2 RIOK1

Reference Transcript

RefSeq:NM_031480.2 RIOK1

Other Identifiers

11730139_a_at

11733924_a_at

11733925_a_at

17004582

224450_PM_s_at

224450_s_at

2893722

2893723

2893726

2893727

2893729

2893730

2893731

2893732

2893735

2893736

2893737

2893738

2893739

2893740

2893741

2893742

2893743

2893744

2893745

2893747

2893749

2893750

2893751

2893752

2893753

2893756

2893757

2893758

2893759

51703_at

73522_at

81163_at

8116760

83732

A_14_P120232

A_24_P8088

A_24_P93798

GE83260

GO:0003824

GO:0004674

GO:0005515

GO:0005524

GO:0005654

GO:0005737

GO:0005829

GO:0016740

GO:0016787

GO:0030490

GO:0030688

GO:0034708

GO:0042254

GO:0042274

GO:0046872

GO:0106310

GO:0140096

GO:2000234

HMNXSV003055170

ILMN_1652487

ILMN_1670318

ILMN_1797534

PH_hs_0025610

TC06000058.hg

g13543921_3p_s_at

Participates

as an output of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

Other forms of this molecule

RIOK1 [nucleoplasm]

Inferred To

RIOK1 [cytosol] (Bos taurus)

RIOK1 [cytosol] (Caenorhabditis elegans)

RIOK1 [cytosol] (Canis familiaris)

RIOK1 [cytosol] (Drosophila melanogaster)

RIOK1 [cytosol] (Mus musculus)

RIOK1 [cytosol] (Rattus norvegicus)

Cross References

ZINC - World Drugs

RIOK1_HUMAN

Guide to Pharmacology - Targets

2186

OpenTargets

ENSG00000124784

ENSEMBL

ENSP00000369162, ENST00000379834

ZINC - FDA approved

RIOK1_HUMAN

ZINC - Substances

RIOK1_HUMAN

ZINC - Biogenic

RIOK1_HUMAN

ZINC target

Q9BRS2

PRO

Q9BRS2

PDB

7BOC, 6V0N, 4OTP, 6ZXD, 6ZXE, 6ZXF, 6ZXG, 6ZXH, 6ZV6, 6G5I

ZINC - Investigational

RIOK1_HUMAN

HPA

ENSG00000124784-RIOK1

Pharos - Targets

Q9BRS2

ZINC - Predictions - Purchasable

RIOK1_HUMAN

HMDB Protein

HMDBP01414

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.708	6
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.643	3
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:Q9NY12 GAR1	1	GAR1 [nucleoplasm] (R-HSA-6790707)	0.527	3
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:Q14011 CIRBP			0.527	3
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.527	2
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	3
UniProt:P62312 LSM6	2	LSM6 [nucleoplasm] (R-HSA-6806794) LSM6 [cytosol] (R-HSA-429936)	0.527	3
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	3
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.508	2