Reactome | EXOSC10 [nucleoplasm]

EXOSC10 [nucleoplasm]

Stable Identifier

R-HSA-6791547

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Exosome component 10 ecNumber3.1.13.-/ecNumber, EXOSX_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q01780 EXOSC10

Expand all

External Reference Information

External Reference

UniProt:Q01780 EXOSC10

Gene Names

EXOSC10, PMSCL, PMSCL2, RRP6

Chain

chain:1-885

Reference Genes

BioGPS Gene:5394 EXOSC10

COSMIC (genes):EXOSC10 EXOSC10

CTD Gene:5394 EXOSC10

dbSNP Gene:5394 EXOSC10

ENSEMBL:ENSG00000171824 EXOSC10

ENSEMBL_homo_sapiens_GENE:ENSG00000171824.14 EXOSC10

HGNC:9138 EXOSC10

KEGG Gene (Homo sapiens):5394 EXOSC10

Monarch:5394 EXOSC10

NCBI Gene:5394 EXOSC10

OMIM:605960 EXOSC10

UCSC:Q01780 EXOSC10

Reference Transcript

Other Identifiers

11717510_a_at

11747516_a_at

16681625

207541_PM_s_at

207541_s_at

2396481

2396482

2396483

2396484

2396487

2396488

2396489

2396492

2396494

2396496

2396498

2396499

2396500

2396501

2396504

2396507

2396509

2396510

2396512

2396513

2396514

2396517

2396520

2396521

2396522

2396523

2396524

2396525

2396526

2396527

2396529

2396531

2396532

2396533

36649_at

5394

7912385

89673_s_at

A_23_P62868

GE59921

GO:0000166

GO:0000175

GO:0000176

GO:0000177

GO:0000178

GO:0000184

GO:0000460

GO:0000467

GO:0000791

GO:0000956

GO:0003676

GO:0003723

GO:0003727

GO:0003824

GO:0004518

GO:0004527

GO:0004532

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006139

GO:0006281

GO:0006364

GO:0006396

GO:0006399

GO:0006401

GO:0006974

GO:0008408

GO:0016020

GO:0016071

GO:0016073

GO:0016787

GO:0032040

GO:0032200

GO:0032211

GO:0042254

GO:0042274

GO:0043226

GO:0044237

GO:0046872

GO:0070034

GO:0071028

GO:0071034

GO:0071035

GO:0071036

GO:0071037

GO:0071038

GO:0071039

GO:0071040

GO:0071044

GO:0071051

GO:0071840

GO:0101019

GO:0140098

GO:1904872

GO:1905746

HMNXSV003012493

ILMN_1670796

ILMN_1711189

ILMN_2402168

PH_hs_0023791

PH_hs_0032653

TC01002196.hg

X66113_s_at

g4505916_3p_a_at

Participates

as a component of

EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

Inferred To

EXOSC10 [nucleoplasm] (Bos taurus)

EXOSC10 [nucleoplasm] (Caenorhabditis elegans)

EXOSC10 [nucleoplasm] (Canis familiaris)

EXOSC10 [nucleoplasm] (Drosophila melanogaster)

EXOSC10 [nucleoplasm] (Gallus gallus)

EXOSC10 [nucleoplasm] (Mus musculus)

EXOSC10 [nucleoplasm] (Plasmodium falciparum)

EXOSC10 [nucleoplasm] (Rattus norvegicus)

EXOSC10 [nucleoplasm] (Saccharomyces cerevisiae)

EXOSC10 [nucleoplasm] (Schizosaccharomyces pombe)

EXOSC10 [nucleoplasm] (Sus scrofa)

exosc10 [nucleoplasm] (Dictyostelium discoideum)

exosc10 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002676.1, NP_001001998.1

OpenTargets

ENSG00000171824

HPA

ENSG00000171824-EXOSC10

GeneCards

Q01780

Ensembl

ENSG00000171824, ENSP00000307307, ENST00000376936, ENST00000304457, ENSP00000366135

PRO

Q01780

Pharos - Targets

Q01780

PDB

6D6R, 3SAH, 3SAF, 7MQA, 3SAG, 6D6Q, 2CPR

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.886	8
UniProt:Q9NPD3 EXOSC4	2	EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.845	7
UniProt:Q13868 EXOSC2	2	EXOSC2 [nucleoplasm] (R-HSA-6791582) EXOSC2 [cytosol] (R-HSA-429999)	0.837	7
UniProt:Q9Y3B2 EXOSC1	2	EXOSC1 [nucleoplasm] (R-HSA-6791578) EXOSC1 [cytosol] (R-HSA-429841)	0.813	7
UniProt:Q99547 MPHOSPH6	1	MPHOSPH6 [nucleoplasm] (R-HSA-6791553)	0.807	7
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.788	7
UniProt:Q15024 EXOSC7	2	EXOSC7 [nucleoplasm] (R-HSA-6791543) EXOSC7 [cytosol] (R-HSA-430030)	0.752	5
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.738	4
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.733	7
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.659	3
UniProt:Q06265 EXOSC9	2	EXOSC9 [nucleoplasm] (R-HSA-6791577) EXOSC9 [cytosol] (R-HSA-429984)	0.643	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.615	3
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.547	2
UniProt:Q8TF46 DI3L1			0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.471	3

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