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EXOSC10 [nucleoplasm]
Stable Identifier
R-HSA-6791547
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Exosome component 10 ecNumber3.1.13.-/ecNumber, EXOSX_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q13901 C1D
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
EXOSC10 [nucleoplasm] (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
EXOSC10 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
EXOSC10 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01780 EXOSC10
Gene Names
EXOSC10, PMSCL, PMSCL2, RRP6
Chain
chain:1-885
Reference Genes
BioGPS Gene:5394 EXOSC10
COSMIC (genes):EXOSC10 EXOSC10
CTD Gene:5394 EXOSC10
dbSNP Gene:5394 EXOSC10
ENSEMBL:ENSG00000171824 EXOSC10
HGNC:9138 EXOSC10
Monarch:5394 EXOSC10
NCBI Gene:5394 EXOSC10
OMIM:605960 EXOSC10
UCSC:Q01780 EXOSC10
Reference Transcript
RefSeq:NM_001001998.2 EXOSC10
RefSeq:NM_002685.3 EXOSC10
Other Identifiers
11717510_a_at
11747516_a_at
16681625
207541_PM_s_at
207541_s_at
2396481
2396482
2396483
2396484
2396486
2396487
2396488
2396489
2396490
2396492
2396494
2396495
2396496
2396497
2396498
2396499
2396500
2396501
2396502
2396503
2396504
2396505
2396506
2396507
2396508
2396509
2396510
2396511
2396512
2396513
2396514
2396516
2396517
2396520
2396521
2396522
2396523
2396524
2396525
2396526
2396527
2396528
2396529
2396531
2396532
2396533
36649_at
5394
7912385
89673_s_at
A_23_P62868
GE59921
GO:0000166
GO:0000175
GO:0000176
GO:0000177
GO:0000178
GO:0000184
GO:0000460
GO:0000467
GO:0000791
GO:0000956
GO:0003676
GO:0003723
GO:0003727
GO:0003824
GO:0004527
GO:0004532
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006139
GO:0006281
GO:0006364
GO:0006396
GO:0006399
GO:0006401
GO:0008408
GO:0016020
GO:0016071
GO:0016073
GO:0016787
GO:0032040
GO:0032211
GO:0042274
GO:0043226
GO:0044237
GO:0046872
GO:0070034
GO:0071028
GO:0071034
GO:0071035
GO:0071036
GO:0071037
GO:0071038
GO:0071039
GO:0071040
GO:0071044
GO:0071051
GO:0101019
GO:0140098
GO:1904872
GO:1905746
HMNXSV003012493
Hs2.321234.1.S1_3p_at
ILMN_1670796
ILMN_1711189
ILMN_2402168
PH_hs_0023791
PH_hs_0032653
TC01002196.hg
X66113_s_at
g4505916_3p_a_at
Participates
as a component of
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
(Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA
(Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA
(Homo sapiens)
Inferred To
EXOSC10 [nucleoplasm]
(Bos taurus)
EXOSC10 [nucleoplasm]
(Caenorhabditis elegans)
EXOSC10 [nucleoplasm]
(Canis familiaris)
EXOSC10 [nucleoplasm]
(Drosophila melanogaster)
EXOSC10 [nucleoplasm]
(Gallus gallus)
EXOSC10 [nucleoplasm]
(Mus musculus)
EXOSC10 [nucleoplasm]
(Plasmodium falciparum)
EXOSC10 [nucleoplasm]
(Rattus norvegicus)
EXOSC10 [nucleoplasm]
(Saccharomyces cerevisiae)
EXOSC10 [nucleoplasm]
(Schizosaccharomyces pombe)
EXOSC10 [nucleoplasm]
(Sus scrofa)
exosc10 [nucleoplasm]
(Dictyostelium discoideum)
exosc10 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000307307
,
ENST00000304457
,
ENST00000376936
,
ENSP00000366135
OpenTargets
ENSG00000171824
HPA
ENSG00000171824-EXOSC10
PRO
Q01780
Pharos - Targets
Q01780
GlyGen
Q01780
PDB
3SAG
,
3SAF
,
7MQA
,
6D6Q
,
3SAH
,
6D6R
,
2CPR
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.886
8
UniProt:Q9NPD3 EXOSC4
2
EXOSC4 [nucleoplasm]
(R-HSA-6791503)
EXOSC4 [cytosol]
(R-HSA-430013)
0.845
7
UniProt:Q13868 EXOSC2
2
EXOSC2 [nucleoplasm]
(R-HSA-6791582)
EXOSC2 [cytosol]
(R-HSA-429999)
0.837
7
UniProt:Q9Y3B2 EXOSC1
2
EXOSC1 [nucleoplasm]
(R-HSA-6791578)
EXOSC1 [cytosol]
(R-HSA-429841)
0.813
7
UniProt:Q99547 MPHOSPH6
1
MPHOSPH6 [nucleoplasm]
(R-HSA-6791553)
0.807
7
UniProt:Q9NQT5 EXOSC3
2
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
EXOSC3 [cytosol]
(R-HSA-430017)
0.788
7
UniProt:Q15024 EXOSC7
2
EXOSC7 [nucleoplasm]
(R-HSA-6791543)
EXOSC7 [cytosol]
(R-HSA-430030)
0.752
5
UniProt:Q9Y2L1 DIS3
2
DIS3 [nucleoplasm]
(R-HSA-6791517)
DIS3 [cytosol]
(R-HSA-429935)
0.738
4
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.733
7
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.659
3
UniProt:Q06265 EXOSC9
2
EXOSC9 [nucleoplasm]
(R-HSA-6791577)
EXOSC9 [cytosol]
(R-HSA-429984)
0.643
3
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.615
3
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.547
2
UniProt:Q9Y580 RBM7
1
RBM7 [nucleoplasm]
(R-HSA-8985564)
0.527
2
UniProt:Q8TF46 DI3L1
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
2
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.471
3
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