Reactome | MPHOSPH6 [nucleoplasm]

MPHOSPH6 [nucleoplasm]

Stable Identifier

R-HSA-6791553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

M-phase phosphoprotein 6, MPH6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99547 MPHOSPH6

Gene Names

MPHOSPH6, MPP6

Chain

chain:1-160

Reference Genes

BioGPS Gene:10200 MPHOSPH6

COSMIC (genes):MPHOSPH6 MPHOSPH6

CTD Gene:10200 MPHOSPH6

dbSNP Gene:10200 MPHOSPH6

ENSEMBL:ENSG00000135698.10 MPHOSPH6

HGNC:7214 MPHOSPH6

KEGG Gene (Homo sapiens):10200 MPHOSPH6

Monarch:10200 MPHOSPH6

NCBI Gene:10200 MPHOSPH6

OMIM:605500 MPHOSPH6

UCSC:Q99547 MPHOSPH6

Reference Transcript

RefSeq:NM_005792.2 MPHOSPH6

Other Identifiers

0005290075

10200

11743466_at

16828705

203740_PM_at

203740_at

31864_at

3701839

3701840

3701841

3701843

3701846

3701854

3701855

3701858

3701859

8003068

A_23_P140848

GE60204

GO:0000176

GO:0000178

GO:0000460

GO:0003723

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0032991

GO:0042254

GO:0043226

HMNXSV003029341

ILMN_1746682

ILMN_1781360

PH_hs_0023895

TC16001302.hg

X98263_at

g5031918_3p_at

Participates

as a component of

EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)

Inferred To

zgc:100960 [nucleoplasm] (Danio rerio)

Ghost homologue of MPHOSPH6 [nucleoplasm] (Saccharomyces cerevisiae)

Mphosph6 [nucleoplasm] (Mus musculus)

Mphosph6 [nucleoplasm] (Rattus norvegicus)

MPHOSPH6 [nucleoplasm] (Bos taurus)

MPHOSPH6 [nucleoplasm] (Caenorhabditis elegans)

MPHOSPH6 [nucleoplasm] (Canis familiaris)

MPHOSPH6 [nucleoplasm] (Dictyostelium discoideum)

MPHOSPH6 [nucleoplasm] (Gallus gallus)

MPHOSPH6 [nucleoplasm] (Schizosaccharomyces pombe)

MPHOSPH6 [nucleoplasm] (Sus scrofa)

Mpp6 [nucleoplasm] (Drosophila melanogaster)

mphosph6 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005783.2

OpenTargets

ENSG00000135698

GeneCards

Q99547

HPA

ENSG00000135698-MPHOSPH6

Ensembl

ENSG00000135698, ENSP00000258169, ENST00000258169

PRO

Q99547

Pharos - Targets

Q99547

PDB

6D6Q, 6D6R, 6H25

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.75	4
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.643	3
UniProt:Q13868 EXOSC2	2	EXOSC2 [nucleoplasm] (R-HSA-6791582) EXOSC2 [cytosol] (R-HSA-429999)	0.623	3
UniProt:P42285 MTREX	1	SKIV2L2 [nucleoplasm] (R-HSA-6791189)	0.592	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.564	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9NPD3 EXOSC4	2	EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.527	2

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