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MPHOSPH6 [nucleoplasm]
Stable Identifier
R-HSA-6791553
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
M-phase phosphoprotein 6, MPH6_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q01780 EXOSC10
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
MPHOSPH6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99547 MPHOSPH6
Gene Names
MPHOSPH6, MPP6
Chain
chain:1-160
Reference Genes
BioGPS Gene:10200 MPHOSPH6
COSMIC (genes):MPHOSPH6 MPHOSPH6
COSMIC (genes):MPP6 MPHOSPH6
CTD Gene:10200 MPHOSPH6
dbSNP Gene:10200 MPHOSPH6
ENSEMBL:ENSG00000135698 MPHOSPH6
HGNC:7214 MPHOSPH6
Monarch:10200 MPHOSPH6
NCBI Gene:10200 MPHOSPH6
OMIM:605500 MPHOSPH6
UCSC:Q99547 MPHOSPH6
Reference Transcript
RefSeq:NM_005792.2 MPHOSPH6
Other Identifiers
10200
11743466_at
11761580_at
11761581_x_at
1554906_PM_a_at
1554906_a_at
16828705
203740_PM_at
203740_at
31864_at
3701839
3701840
3701841
3701843
3701845
3701846
3701852
3701853
3701854
3701855
3701857
3701858
3701859
8003068
A_23_P140848
A_24_P926529
GE60204
GO:0000176
GO:0000178
GO:0000460
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006364
GO:0043226
HMNXSV003029341
Hs2.331968.1.S1_3p_s_at
ILMN_1781360
PH_hs_0023895
PH_hs_0037364
TC16001302.hg
X98263_at
g5031918_3p_at
Participates
as a component of
EXOSC10:C1D:MPHOSPH6 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
(Homo sapiens)
Inferred To
Ghost homologue of MPHOSPH6 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of MPHOSPH6 [nucleoplasm]
(Saccharomyces cerevisiae)
Mphosph6 [nucleoplasm]
(Mus musculus)
Mphosph6 [nucleoplasm]
(Rattus norvegicus)
MPHOSPH6 [nucleoplasm]
(Bos taurus)
MPHOSPH6 [nucleoplasm]
(Caenorhabditis elegans)
MPHOSPH6 [nucleoplasm]
(Canis familiaris)
MPHOSPH6 [nucleoplasm]
(Dictyostelium discoideum)
MPHOSPH6 [nucleoplasm]
(Gallus gallus)
MPHOSPH6 [nucleoplasm]
(Schizosaccharomyces pombe)
MPHOSPH6 [nucleoplasm]
(Sus scrofa)
Mpp6 [nucleoplasm]
(Drosophila melanogaster)
mphosph6 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000258169
,
ENSP00000258169
OpenTargets
ENSG00000135698
HPA
ENSG00000135698-MPHOSPH6
PRO
Q99547
Pharos - Targets
Q99547
GlyGen
Q99547
PDB
6H25
,
6D6Q
,
6D6R
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.807
7
UniProt:Q9NQT5 EXOSC3
2
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
EXOSC3 [cytosol]
(R-HSA-430017)
0.725
6
UniProt:Q13868 EXOSC2
2
EXOSC2 [nucleoplasm]
(R-HSA-6791582)
EXOSC2 [cytosol]
(R-HSA-429999)
0.708
6
UniProt:P42285 SKIV2L2
1
SKIV2L2 [nucleoplasm]
(R-HSA-6791189)
0.693
3
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.669
5
UniProt:Q9NPD3 EXOSC4
2
EXOSC4 [nucleoplasm]
(R-HSA-6791503)
EXOSC4 [cytosol]
(R-HSA-430013)
0.643
5
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.615
5
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.527
4
UniProt:Q9Y3B2 EXOSC1
2
EXOSC1 [nucleoplasm]
(R-HSA-6791578)
EXOSC1 [cytosol]
(R-HSA-429841)
0.527
5
UniProt:Q15024 EXOSC7
2
EXOSC7 [nucleoplasm]
(R-HSA-6791543)
EXOSC7 [cytosol]
(R-HSA-430030)
0.527
4
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