32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The PeBoW complex and the Rix1:LAS1L:NOL9:SENP3 complex associate with pre-60S ribosome subunits during maturation and are required for efficient rRNA processing. Note that this complex contains many ribsomal subunit proteins and processing factors but the precise composition is not known.

Literature References
PubMed ID Title Journal Year
16738141 Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex

Grimm, T, Hölzel, M, Rohrmoser, M, Harasim, T, Malamoussi, A, Gruber-Eber, A, Kremmer, E, Eick, D

Nucleic Acids Res. 2006
17353269 Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit

Rohrmoser, M, Hölzel, M, Grimm, T, Malamoussi, A, Harasim, T, Orban, M, Pfisterer, I, Gruber-Eber, A, Kremmer, E, Eick, D

Mol. Cell. Biol. 2007
16043514 Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation

Hölzel, M, Rohrmoser, M, Schlee, M, Grimm, T, Harasim, T, Malamoussi, A, Gruber-Eber, A, Kremmer, E, Hiddemann, W, Bornkamm, GW, Eick, D

J. Cell Biol. 2005
17189298 The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing

Hölzel, M, Grimm, T, Rohrmoser, M, Malamoussi, A, Harasim, T, Gruber-Eber, A, Kremmer, E, Eick, D

Nucleic Acids Res. 2007
22190735 LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

Castle, CD, Cassimere, EK, Denicourt, C

Mol. Biol. Cell 2012
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