Reactome | EXOSC8 [nucleoplasm]

EXOSC8 [nucleoplasm]

Stable Identifier

R-HSA-6791571

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Exosome complex component RRP43, EXOS8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96B26 EXOSC8

Gene Names

EXOSC8, OIP2, RRP43

Chain

initiator methionine:, chain:2-276

Reference Genes

BioGPS Gene:11340 EXOSC8

COSMIC (genes):EXOSC8 EXOSC8

CTD Gene:11340 EXOSC8

dbSNP Gene:11340 EXOSC8

ENSEMBL:ENSG00000120699 EXOSC8

HGNC:17035 EXOSC8

KEGG:hsa:11340 EXOSC8

Monarch:11340 EXOSC8

NCBI Gene:11340 EXOSC8

OMIM:606019 EXOSC8

UCSC:Q96B26 EXOSC8

Reference Transcript

RefSeq:NM_181503.2 EXOSC8

Other Identifiers

11340

11717589_a_at

16774082

215136_PM_s_at

215136_s_at

2954850

3485864

3485865

3485866

3485867

3485868

3485869

3485870

3485872

3485873

3485874

3485875

3485876

3485877

3485878

3485879

3485880

3485881

3485882

3485883

3485884

3485885

3485887

3485888

3485889

3485890

3485891

3485892

3485894

3485896

36968_s_at

67646_f_at

7968658

92006_s_at

A_14_P110649

A_23_P162822

A_24_P241276

GE79411

GE794905

GO:0000176

GO:0000177

GO:0000178

GO:0000288

GO:0000467

GO:0000956

GO:0001650

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0006396

GO:0006399

GO:0006401

GO:0009057

GO:0016071

GO:0016073

GO:0034473

GO:0034475

GO:0034476

GO:0035925

GO:0042802

GO:0043226

GO:0043231

GO:0044248

GO:0071028

GO:0071035

GO:0071038

GO:0101019

GO:1902494

HMNXSV003012352

Hs.274170.1.S1_3p_a_at

ILMN_1756162

PH_hs_0014123

TC13000128.hg

TC13001019.hg

p26668

Participates

as a component of

Exosome core complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

EXOSC8 [cytosol]

Inferred To

RRP43 [nucleoplasm] (Saccharomyces cerevisiae)

EXOSC8 [nucleoplasm] (Bos taurus)

EXOSC8 [nucleoplasm] (Canis familiaris)

EXOSC8 [nucleoplasm] (Dictyostelium discoideum)

EXOSC8 [nucleoplasm] (Gallus gallus)

EXOSC8 [nucleoplasm] (Sus scrofa)

Exosc8 [nucleoplasm] (Mus musculus)

Exosc8 [nucleoplasm] (Rattus norvegicus)

exos-8 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of EXOSC8 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of EXOSC8 [nucleoplasm] (Plasmodium falciparum)

rrp43 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_852480.1

ENSEMBL

ENSP00000374354, ENST00000389704

OpenTargets

ENSG00000120699

HPA

ENSG00000120699-EXOSC8

PRO

Q96B26

Pharos - Targets

Q96B26

GlyGen

Q96B26

Orphanet

EXOSC8

PDB

6D6Q, 2NN6, 6D6R, 6H25

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.948	25
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.659	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.556	3
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.547	2
UniProt:Q99547 MPHOSPH6	1	MPHOSPH6 [nucleoplasm] (R-HSA-6791553)	0.527	4
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.527	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.527	3
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2

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