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Lipo-K107-GCSH [mitochondrial matrix]
Stable Identifier
R-HSA-6793611
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Glycine cleavage system H protein, mitochondrial, GCSH_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Glycine degradation (Homo sapiens)
DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)
Lipo-K107-GCSH [mitochondrial matrix] (Homo sapiens)
PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)
Lipo-K107-GCSH [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein lipoylation (Homo sapiens)
LIAS synthesizes lipoyl-GCSH (Homo sapiens)
Lipo-K107-GCSH [mitochondrial matrix] (Homo sapiens)
LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Homo sapiens)
Lipo-K107-GCSH [mitochondrial matrix] (Homo sapiens)
LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Homo sapiens)
Lipo-K107-GCSH [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23434 GCSH
Gene Names
GCSH
Chain
transit peptide:1-48, chain:49-173
Reference Genes
BioGPS Gene:2653 GCSH
COSMIC (genes):GCSH GCSH
CTD Gene:2653 GCSH
dbSNP Gene:2653 GCSH
ENSEMBL:ENSG00000140905 GCSH
ENSEMBL_homo_sapiens_GENE:ENSG00000140905.11 GCSH
ENSEMBL_homo_sapiens_GENE:ENSG00000291958.1 GCSH
HGNC:4208 GCSH
KEGG Gene (Homo sapiens):2653 GCSH
Monarch:2653 GCSH
NCBI Gene:2653 GCSH
OMIM:238330 GCSH
UCSC:P23434 GCSH
Reference Transcript
RefSeq:NM_004483.4 GCSH
Other Identifiers
11742888_s_at
11756405_s_at
11757061_s_at
11757936_s_at
11759414_at
16828640
213129_PM_s_at
213129_s_at
213133_PM_s_at
213133_s_at
2442901
2442902
2442903
2442904
2442905
2442906
2596204
2653
2804570
2851483
3701461
3701462
3701463
3701464
3701466
3701468
3701471
3701476
3701477
3701480
37357_at
7922104
8002999
8114778
A_23_P117933
D00723_at
GE57037
GO:0003824
GO:0004047
GO:0005515
GO:0005737
GO:0005739
GO:0005759
GO:0005960
GO:0006520
GO:0006546
GO:0009249
GO:0016740
GO:0019464
GO:0036211
GO:0043226
GO:0051604
GO:1990204
HMNXSV003009055
Hs.77631.1.A1_3p_a_at
Hs.77631.1.A2_3p_a_at
ILMN_1666403
ILMN_2090782
ILMN_2090786
PH_hs_0030733
TC16001298.hg
TC16001983.hg
p33441
Participates
as an input of
PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)
LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Homo sapiens)
LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Homo sapiens)
as an output of
DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)
LIAS synthesizes lipoyl-GCSH (Homo sapiens)
Other forms of this molecule
octanoyl-K107-GCSH [mitochondrial matrix]
GCSH [mitochondrial matrix]
Inferred To
GCV3 [mitochondrial matrix]
(Saccharomyces cerevisiae)
gcsh [mitochondrial matrix]
(Xenopus tropicalis)
gcsh-2 [mitochondrial matrix]
(Caenorhabditis elegans)
gcv3 [mitochondrial matrix]
(Schizosaccharomyces pombe)
gcvH2 [mitochondrial matrix]
(Dictyostelium discoideum)
gcsha [mitochondrial matrix]
(Danio rerio)
ppl [mitochondrial matrix]
(Drosophila melanogaster)
GCSH [mitochondrial matrix]
(Bos taurus)
GCSH [mitochondrial matrix]
(Gallus gallus)
GCSH [mitochondrial matrix]
(Sus scrofa)
Gcsh [mitochondrial matrix]
(Mus musculus)
Gcsh [mitochondrial matrix]
(Rattus norvegicus)
Lipo-K107-GCSH [mitochondrial matrix]
(Canis familiaris)
Lipo-K107-GCSH [mitochondrial matrix]
(Plasmodium falciparum)
Modified Residues
Name
N6-lipoyl-L-lysine at 107
Coordinate
107
PsiMod Name
N6-lipoyl-L-lysine [MOD:00127]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.
Cross References
RefSeq
NP_004474.2
Guide to Pharmacology - Targets
3098
OpenTargets
ENSG00000140905
GeneCards
P23434
HPA
ENSG00000140905-GCSH
Ensembl
ENSG00000140905
,
ENST00000315467
,
ENSP00000319531
PRO
P23434
Pharos - Targets
P23434
Orphanet
16112
HMDB Protein
HMDBP03058
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13287 NMI
1
NMI [cytosol]
(R-HSA-9731022)
0.666
4
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:Q9P086 MED11
1
MED11 [nucleoplasm]
(R-HSA-556808)
0.556
3
UniProt:P43360 MAGA6
0.556
3
UniProt:Q9UHD4 CIDEB
0.556
3
UniProt:P43364 MAGAB
0.556
3
UniProt:Q9NYP9 MIS18A
1
MIS18A [nucleoplasm]
(R-HSA-606299)
0.556
3
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