Phosphorylated Signal transducer and activator of transcription 6 (STAT6) dimers translocate to the nucleus and activate the transcription of several genes. In experimental models, targeted gene disruption of STAT6 inhibited airway hyperresponsiveness, airway inflammation, and fibrosis (Blease et al. 2002). STAT6 promotes transcription of the cell surface proteins Interleukin-4 receptor alpha (IL4R) (Matsukura et al. 1999) and Low affinity immunoglobulin epsilon Fc receptor (FCER2) (Takeda et al. 1994, Park et al. 1998). IL4 links the immune system to the opioid system by inducing transcription of the mu- and delta-opioid receptors (MOR, DOR) (Borner et al. 2004, Kraus et al. 2001) and pro-opiomelanocortin (POMC) (Busch-Dienstfertig et al. 2012). Opioid receptor gene expression in T cells is STAT6-dependent while POMC gene expression in lymphocytes is mediated by STAT3 (Busch-Dienstfertig & González-Rodríguez 2013).
Yoshida, N, Shi, W, Kishimoto, T, Nakanishi, K, Matsumoto, M, Akira, S, Kashiwamura, S, Tanaka, T, Minami, M, Takeda, K
So, EY, Lee, CE, Park, HJ
Frischauf, AM, Schmiedlechner, A, Duschl, A, Aberger, F, Luft, P, Hebenstreit, D, Horejs-Hoeck, J, Regl, G
Casolaro, V, Georas, SN, Miura, K, Stellato, C, Matsukura, S, Schleimer, RP, Plitt, JR, Bickel, C
Höllt, V, Kraus, J, Wöltje, M, Börner, C
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