Reactome | DLGAP1 [plasma membrane]

DLGAP1 [plasma membrane]

Stable Identifier

R-HSA-6794239

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Disks large-associated protein 1, DLGP1_HUMAN, GKAP1

Icon

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - ABP1 binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)
    - GKAPs bind PSD-95 members (Homo sapiens)
      - GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)
    - HOMER binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)
    - SHANK proteins bind GKAPs (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        GKAP1-4 [plasma membrane] (Homo sapiens)
        
        DLGAP1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14490 DLGAP1

Gene Names

DLGAP1, DAP1, GKAP

Chain

chain:1-977

Reference Genes

BioGPS Gene:9229 DLGAP1

COSMIC (genes):DLGAP1 DLGAP1

CTD Gene:9229 DLGAP1

dbSNP Gene:9229 DLGAP1

ENSEMBL:ENSG00000170579 DLGAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000170579.19 DLGAP1

HGNC:2905 DLGAP1

KEGG Gene (Homo sapiens):9229 DLGAP1

Monarch:9229 DLGAP1

NCBI Gene:9229 DLGAP1

OMIM:605445 DLGAP1

UCSC:O14490 DLGAP1

Reference Transcript

Other Identifiers

11736924_a_at

11737597_x_at

11745111_a_at

11747695_x_at

11748640_a_at

11760366_a_at

11760367_x_at

139_at

16853580

206489_PM_s_at

206489_s_at

206490_PM_at

206490_at

210750_PM_s_at

210750_s_at

235527_PM_at

235527_at

2405933

3796621

3796622

3796623

3796626

3796627

3796629

3796646

3796647

3796656

3796657

3796658

3796659

3796667

3796694

3796695

3796699

3796725

3796735

3796736

3796742

3796744

3796745

3796746

3796747

3796777

3796793

3796828

3796829

40388_at

56008_at

8022085

90725_r_at

9229

A_24_P62367

GE53011

GO:0005515

GO:0005575

GO:0005886

GO:0007268

GO:0014069

GO:0016020

GO:0023052

GO:0043226

GO:0044877

GO:0045202

GO:0060090

GO:0098978

GO:0099572

HMNXSV003036613

HMNXSV003049246

Hs.290270.0.A1_3p_at

Hs.290270.0.A1_3p_x_at

ILMN_1740450

ILMN_1742549

ILMN_1805654

ILMN_2380779

PH_hs_0031710

U67988_at

g2588977_3p_a_at

g4758165_3p_at

Participates

as a member of

GKAP1-4 [plasma membrane] (Homo sapiens)

Inferred To

mars [plasma membrane] (Drosophila melanogaster)

Homologues of DLGAP1 [plasma membrane] (Drosophila melanogaster)

DLGAP1 [plasma membrane] (Bos taurus)

DLGAP1 [plasma membrane] (Canis familiaris)

DLGAP1 [plasma membrane] (Sus scrofa)

Dlgap1 [plasma membrane] (Mus musculus)

Dlgap1 [plasma membrane] (Rattus norvegicus)

vlc [plasma membrane] (Drosophila melanogaster)

dlgap1 [plasma membrane] (Danio rerio)

dlgap1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001229691.1, NP_001229695.1, NP_001003809.1, NP_001229690.1, NP_001229693.1, NP_001229694.1, NP_004737.2, NP_001229692.1

OpenTargets

ENSG00000170579

GeneCards

O14490

HPA

ENSG00000170579-DLGAP1

Ensembl

ENSP00000463864, ENSP00000446312, ENSP00000437817, ENST00000581699, ENSP00000383019, ENST00000581527, ENSP00000316377, ENST00000400147, ENST00000400145, ENSP00000383010, ENSP00000462848, ENSP00000383011, ENST00000315677, ENSG00000170579, ENST00000539435, ENST00000400155, ENST00000534970

PRO

O14490

Pharos - Targets

O14490

PDB

5YPO, 6TNQ, 6TQ0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78352 DLG4	3	DLG4 [cytosol] (R-HSA-6794267) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135)	0.592	6
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	3