Reactome | APBA3 [cytosol]

APBA3 [cytosol]

Stable Identifier

R-HSA-6794262

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Amyloid beta A4 precursor protein-binding family A member 3, APBA3_HUMAN, MINT3

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - NRXNs binds MUNC18 (Homo sapiens)
      - NRXNs:STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        MINT1,2,(3) [cytosol] (Homo sapiens)
        
        APBA3 [cytosol] (Homo sapiens)
      - STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        MINT1,2,(3) [cytosol] (Homo sapiens)
        
        APBA3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O96018 APBA3

Gene Names

APBA3, MINT3, X11L2

Chain

chain:1-575

Reference Genes

BioGPS Gene:9546 APBA3

COSMIC (genes):APBA3 APBA3

CTD Gene:9546 APBA3

dbSNP Gene:9546 APBA3

ENSEMBL:ENSG00000011132 APBA3

HGNC:580 APBA3

KEGG:hsa:9546 APBA3

Monarch:9546 APBA3

NCBI Gene:9546 APBA3

OMIM:604262 APBA3

UCSC:O96018 APBA3

Reference Transcript

RefSeq:NM_004886.3 APBA3

Other Identifiers

11755083_a_at

16867135

205146_PM_x_at

205146_x_at

215148_PM_s_at

215148_s_at

3846364

3846365

3846366

3846367

3846368

3846369

3846370

3846371

3846372

3846373

3846374

3846375

3846376

3846377

3846378

3846379

3846380

3846381

3846383

3846384

3846385

3846386

3846387

3846389

38550_at

8032670

9546

A_33_P3295640

GE53587

GO:0001540

GO:0001701

GO:0004857

GO:0005515

GO:0005737

GO:0005886

GO:0007268

GO:0010468

GO:0015031

GO:0019899

GO:0023052

GO:0043086

GO:0043197

GO:0048471

GO:0048856

GO:0098772

HMNXSV003018835

HMNXSV003040741

Hs.17528.1.S1_3p_a_at

ILMN_1686610

PH_hs_0001582

TC19001049.hg

TC19002295.hg

Participates

as a member of

MINT1,2,(3) [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENST00000316757, ENSP00000315136

OpenTargets

ENSG00000011132

HPA

ENSG00000011132-APBA3

PRO

O96018

Pharos - Targets

O96018

GlyGen

O96018

PDB

2YT7, 2YT8, 5UWS

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.666	6
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.527	4
UniProt:P78552 IL13RA1	2	IL13RA1 [plasma membrane] (R-HSA-449671) p-Y-IL13RA1 [plasma membrane] (R-HSA-6786750)	0.527	2
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.499	2

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