Reactome | SPAR [cytosol]

SPAR [cytosol]

Stable Identifier

R-HSA-6794278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SIPA1L1, Signal-induced proliferation-associated 1-like protein 1, SI1L1_HUMAN, Spine-Associated RapGAP (SPAR)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O43166 SIPA1L1

Gene Names

SIPA1L1, E6TP1, KIAA0440

Chain

chain:1-1804

Reference Genes

BioGPS Gene:26037 SIPA1L1

COSMIC (genes):SIPA1L1 SIPA1L1

CTD Gene:26037 SIPA1L1

dbSNP Gene:26037 SIPA1L1

ENSEMBL:ENSG00000197555 SIPA1L1

ENSEMBL_homo_sapiens_GENE:ENSG00000197555.10 SIPA1L1

HGNC:20284 SIPA1L1

KEGG Gene (Homo sapiens):26037 SIPA1L1

Monarch:26037 SIPA1L1

NCBI Gene:26037 SIPA1L1

OMIM:617504 SIPA1L1

UCSC:O43166 SIPA1L1

Reference Transcript

Other Identifiers

11754219_a_at

11763274_a_at

16786010

202254_PM_at

202254_at

202255_PM_s_at

202255_s_at

26037

3542846

3542848

3542885

3542887

3542902

3542903

3542904

3542905

3542906

3542915

3542918

3542927

3542928

3542929

3542931

3542936

3542937

3542938

3542948

3542953

3542956

3542957

3542960

3542961

3542964

3542965

3542966

3542967

3542968

3542971

3542975

3542977

3542978

3542979

3542980

3542981

40805_at

7975459

A_14_P102825

A_14_P106604

A_14_P131288

A_14_P131769

A_23_P76969

A_24_P219094

A_24_P344053

GE53187

GE82015

GO:0003674

GO:0005096

GO:0005515

GO:0005737

GO:0005856

GO:0005886

GO:0007010

GO:0008150

GO:0014069

GO:0015629

GO:0023052

GO:0030036

GO:0030154

GO:0034330

GO:0043005

GO:0043087

GO:0043197

GO:0043226

GO:0045202

GO:0046875

GO:0048013

GO:0048167

GO:0048856

GO:0050770

GO:0051056

GO:0061001

GO:0090630

GO:0098772

HMNXSV003038821

Hs.172180.0.S2_3p_at

ILMN_2128162

PH_hs_0010312

PH_hs_0018191

PH_hs_0031993

TC14000433.hg

TC14001760.hg

g7662125_3p_a_at

p25913

Participates

as a component of

NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)

as an input of

NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)

Cross References

RefSeq

XP_016876649.1, XP_016876662.1, XP_016876653.1, XP_016876675.1, XP_016876659.1, XP_016876680.1, NP_056371.1, XP_011534937.1, XP_016876654.1, XP_016876668.1, XP_016876664.1, XP_016876663.1, XP_016876669.1, XP_011534932.1, XP_016876681.1, XP_016876676.1, XP_016876655.1, XP_016876678.1, NP_001271174.1, XP_016876665.1, XP_005267573.1, XP_011534933.1, XP_016876650.1, XP_016876677.1, XP_016876651.1, XP_016876656.1, XP_016876679.1, XP_016876657.1, XP_016876660.1, NP_001271175.1, XP_016876682.1, XP_016876648.1, XP_016876666.1, XP_016876661.1, XP_016876652.1, XP_016876667.1, XP_011534934.1, XP_016876658.1

OpenTargets

ENSG00000197555

HPA

ENSG00000197555-SIPA1L1

GeneCards

O43166

Ensembl

ENSP00000351352, ENSG00000197555, ENST00000555818, ENST00000358550, ENSP00000370630, ENST00000381232, ENSP00000450832

PRO

O43166

Pharos - Targets

O43166

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03126 VE6			0.621	3
UniProt:P78352 DLG4	3	DLG4 [cytosol] (R-HSA-6794267) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135)	0.592	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.483	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.483	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

Cite Us!