Reactome | PRR5 [cytosol]

PRR5 [cytosol]

Stable Identifier

R-HSA-6795323

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proline-rich protein 5, Protein observed with Rictor-1, Protor-1, PROTOR1, PP610

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - mTORC2 phosphorylates AKT1 on serine-473 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        PRR5 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        TORC2 complex phosphorylates SGK1 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        PRR5 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-stimulation by CD28 (Homo sapiens)
      - CD28 dependent PI3K/Akt signaling (Homo sapiens)
        
        TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        PRR5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P85299 PRR5

Gene Names

PRR5, PROTOR1, PP610

Chain

chain:1-388

Reference Genes

BioGPS Gene:55615 PRR5

COSMIC (genes):PRR5 PRR5

CTD Gene:55615 PRR5

dbSNP Gene:55615 PRR5

ENSEMBL:ENSG00000186654 PRR5

HGNC:31682 PRR5

KEGG:hsa:55615 PRR5

Monarch:55615 PRR5

NCBI Gene:55615 PRR5

OMIM:609406 PRR5

UCSC:P85299 PRR5

Reference Transcript

Participates

as a component of

TORC2 complex [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of PRR5 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PRR5 [cytosol] (Dictyostelium discoideum)

Ghost homologue of PRR5 [cytosol] (Drosophila melanogaster)

bit61 [cytosol] (Schizosaccharomyces pombe)

BIT2 [cytosol] (Saccharomyces cerevisiae)

Prr5 [cytosol] (Mus musculus)

Prr5 [cytosol] (Rattus norvegicus)

BIT61 [cytosol] (Saccharomyces cerevisiae)

PRR5 [cytosol] (Canis familiaris)

PRR5 [cytosol] (Gallus gallus)

PRR5 [cytosol] (Schizosaccharomyces pombe)

PRR5 [cytosol] (Sus scrofa)

Homologues of PRR5 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRR5 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001017530.1, NP_001017528.1, NP_001017529.1, NP_056181.2, NP_001185650.1, NP_851850.1

ENSEMBL

ENST00000403581, ENST00000617066, ENST00000336985, ENSP00000479623, ENSP00000006251, ENST00000006251, ENSP00000384848, ENSG00000186654, ENSP00000337464

OpenTargets

ENSG00000186654

GeneCards

PRR5

HPA

ENSG00000186654-PRR5

PRO

P85299

Pharos - Targets

P85299

GlyGen

P85299

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [cytosol] (R-HSA-416332) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593)	0.609	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.483	3