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p-T256,S422-SGK1 [cytosol]
Stable Identifier
R-HSA-6795449
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser for interactor UniProt:P16220 CREB1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
PDPK1 phosphorylates SGK1 (Homo sapiens)
p-T256,S422-SGK1 [cytosol] (Homo sapiens)
SGK1 phosphorylates MDM2 (Homo sapiens)
p-T256,S422-SGK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PDPK1 phosphorylates SGK1 (Homo sapiens)
p-T256,S422-SGK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00141 SGK1
Gene Names
SGK1, SGK
Chain
chain:1-431
Reference Genes
BioGPS Gene:6446 SGK1
COSMIC (genes):SGK1 SGK1
CTD Gene:6446 SGK1
dbSNP Gene:6446 SGK1
ENSEMBL:ENSG00000118515 SGK1
HGNC:10810 SGK1
KEGG:hsa:6446 SGK1
Monarch:6446 SGK1
NCBI Gene:6446 SGK1
OMIM:602958 SGK1
UCSC:O00141 SGK1
Reference Transcript
RefSeq:XM_011536071.1 SGK1
RefSeq:NM_001143678.1 SGK1
RefSeq:NM_005627.3 SGK1
RefSeq:NM_001291995.1 SGK1
RefSeq:NM_001143676.1 SGK1
RefSeq:NM_001143677.1 SGK1
Other Identifiers
11715931_s_at
11733698_s_at
11737749_a_at
11737750_s_at
17023810
201739_PM_at
201739_at
2975015
2975016
2975017
2975018
2975019
2975020
2975021
2975022
2975023
2975024
2975025
2975026
2975027
2975028
2975029
2975030
2975031
2975032
2975033
2975034
2975035
2975036
2975037
2975038
2975039
2975040
2975041
2975042
2975043
2975044
2975045
2975046
2975047
2975049
2975054
2975057
2975058
2975060
2975068
2975069
2975070
2975077
2975078
2975081
6446
8129677
973_at
A_23_P19673
GE55129
GO:0001558
GO:0003014
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005246
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006355
GO:0006468
GO:0006814
GO:0006915
GO:0006974
GO:0007616
GO:0008217
GO:0008289
GO:0012501
GO:0015459
GO:0016607
GO:0016740
GO:0017080
GO:0017081
GO:0030334
GO:0032411
GO:0035091
GO:0035556
GO:0042127
GO:0042981
GO:0043226
GO:0048812
GO:0050790
GO:0050877
GO:0051090
GO:0060453
GO:0070294
GO:0098772
GO:0106310
GO:0140096
GO:1901796
GO:1904045
HMNXSV003055827
ILMN_1702487
ILMN_1853711
PH_hs_0015329
TC06002126.hg
Y10032_at
g5032090_3p_at
Participates
as an output of
PDPK1 phosphorylates SGK1 (Homo sapiens)
Other forms of this molecule
p-T256,S422-SGK1 [nucleoplasm]
p-S422-SGK1 [cytosol]
SGK1 [cytosol]
Inferred To
Homologues of p-T256,S422-SGK1 [cytosol]
(Dictyostelium discoideum)
Homologues of p-T256,S422-SGK1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of p-T256,S422-SGK1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T256,S422-SGK1 [cytosol]
(Caenorhabditis elegans)
phospho-p-T256,S422-SGK1 [cytosol]
(Danio rerio)
phospho-p-T256,S422-SGK1 [cytosol]
(Dictyostelium discoideum)
phospho-p-T256,S422-SGK1 [cytosol]
(Gallus gallus)
phospho-p-T256,S422-SGK1 [cytosol]
(Mus musculus)
phospho-p-T256,S422-SGK1 [cytosol]
(Rattus norvegicus)
phospho-p-T256,S422-SGK1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T256,S422-SGK1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-T256,S422-SGK1 [cytosol]
(Sus scrofa)
phospho-SGK1 [cytosol]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-serine at 422
Coordinate
422
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 256
Coordinate
256
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001137150.1
,
XP_011534373.1
,
NP_001137148.1
,
NP_001137149.1
,
NP_005618.2
,
NP_001278924.1
Guide to Pharmacology - Targets
1534
OpenTargets
ENSG00000118515
ENSEMBL
ENSP00000356831
,
ENSP00000237305
,
ENST00000367858
,
ENST00000367857
,
ENSP00000434450
,
ENST00000413996
,
ENST00000528577
,
ENSP00000396242
,
ENSP00000356832
HPA
ENSG00000118515-SGK1
ZINC - Substances
SGK1_HUMAN
ZINC target
O00141
PRO
O00141
Pharos - Targets
O00141
ZINC - Predictions - Purchasable
SGK1_HUMAN
PDB
7PUE
,
2R5T
,
3HDN
,
3HDM
HMDB Protein
HMDBP01258
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.564
2
UniProt:P49815 TSC2
4
p-S939,S1130,T1462-TSC2 [cytosol]
(R-HSA-165164)
p-S939,T1462-TSC2 [cytosol]
(R-HSA-199484)
TSC2 [cytosol]
(R-HSA-2980548)
p-S1387-TSC2 [cytosol]
(R-HSA-3132769)
0.563
4
UniProt:O15182 CETN3
0.556
3
UniProt:Q9ULP0-2 NDRG4
0.556
3
UniProt:Q969L2 MAL2
0.556
3
UniProt:Q80UE6 WNK4
0.544
2
UniProt:P16220 CREB1
0.488
2
UniProt:Q9UI14 PRAF1
0.488
2
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