SGK1 phosphorylates MDM2 at serine residues S166 and S188, resulting in MDM2 activation (Amato et al. 2009, Lyo et al. 2010). SGK1 may play a more prominent role in MDM2 activation than AKT (Lyo et al. 2010).
Lyo, D, Foster, DA, Xu, L
Amato, R, Fuiano, G, Rinaldo, C, Costa, N, Soddu, S, Bellacchio, E, D'Antona, L, Mattarocci, S, Paggi, MG, Porciatti, G, Lang, F, Menniti, M, Perrotti, N, Agosti, V
protein serine/threonine kinase activity of p-T256,S422-SGK1 [cytosol]
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