Reactome | PDPK1 phosphorylates SGK1

PDPK1 phosphorylates SGK1

Stable Identifier

R-HSA-6795473

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        PDPK1 phosphorylates SGK1 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PDPK1 (PDK1) activates SGK1 by phosphorylating threonine residue T256, located in the activation loop of SGK1. Phosphorylation of SGK1 at S422 facilitates subsequent phosphorylation at T256 (Kobayashi and Cohen 1999).

Literature References

PubMed ID	Title	Journal	Year
10191262	Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 Cohen, P, Kobayashi, T	Biochem. J.	1999