Reactome | CCNK [nucleoplasm]

CCNK [nucleoplasm]

Stable Identifier

R-HSA-6796619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin-K, CPR4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
        
        P-TEFb complex [nucleoplasm] (Homo sapiens)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)
        
        CCNK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75909 CCNK

Gene Names

CCNK, CPR4

Chain

chain:1-580

Reference Genes

COSMIC (genes):CCNK CCNK

dbSNP Gene:8812 CCNK

ENSEMBL:ENSG00000090061 CCNK

Participates

as a component of

as an input of

as an output of

TP53 stimulates CCNK expression (Homo sapiens)

as a member of

CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)

Inferred To

CCNK [nucleoplasm] (Bos taurus)

CCNK [nucleoplasm] (Canis familiaris)

CCNK [nucleoplasm] (Gallus gallus)

CCNK [nucleoplasm] (Sus scrofa)

ccnk [nucleoplasm] (Danio rerio)

ccnk [nucleoplasm] (Xenopus tropicalis)

pch1 [nucleoplasm] (Schizosaccharomyces pombe)

ccnk-1 [nucleoplasm] (Caenorhabditis elegans)

Ccnk [nucleoplasm] (Mus musculus)

Ccnk [nucleoplasm] (Rattus norvegicus)

BUR2 [nucleoplasm] (Saccharomyces cerevisiae)

cycK [nucleoplasm] (Dictyostelium discoideum)

CycK [nucleoplasm] (Drosophila melanogaster)

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14004 CDK13	3	CDK13 [extracellular region] (R-HSA-6806442) CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374) CDK13 [nucleoplasm] (R-HSA-6797014)	0.826	10
UniProt:Q9NYV4 CDK12	1	CDK12 [nucleoplasm] (R-HSA-6797012)	0.688	5
UniProt:Q93062 RBPMS			0.666	4
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:O14777 NDC80	1	NDC80 [cytosol] (R-HSA-375314)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P54253 ATX1			0.508	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.462	2

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