Reactome | CCNK [nucleoplasm]

CCNK [nucleoplasm]

Stable Identifier

R-HSA-6796619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin-K, CPR4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
        
        P-TEFb complex [nucleoplasm] (Homo sapiens)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)
        
        CCNK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75909 CCNK

Gene Names

CCNK, CPR4

Chain

chain:1-580

Reference Genes

BioGPS Gene:8812 CCNK

COSMIC (genes):CCNK CCNK

CTD Gene:8812 CCNK

dbSNP Gene:8812 CCNK

ENSEMBL:ENSG00000090061.17 CCNK

HGNC:1596 CCNK

KEGG Gene (Homo sapiens):8812 CCNK

Monarch:8812 CCNK

NCBI Gene:8812 CCNK

OMIM:603544 CCNK

UCSC:O75909 CCNK

Reference Transcript

Other Identifiers

0004570736

11738282_a_at

11743735_a_at

16788223

16788250

219273_PM_at

219273_at

225824_PM_at

225824_at

3551306

3551311

3551312

3551314

3551315

3551316

3551317

3551319

3551321

3551322

3551323

3551324

3551328

3551329

3551332

3551333

3551334

3551335

3551336

3551337

3551338

3551339

3551340

65151_at

7976648

8812

90627_at

91009_at

91012_g_at

A_14_P108247

A_23_P3186

A_24_P348925

GE54556

GO:0000079

GO:0000307

GO:0002944

GO:0002945

GO:0004693

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006974

GO:0007049

GO:0008024

GO:0008353

GO:0009966

GO:0016538

GO:0016740

GO:0019901

GO:0023052

GO:0032786

GO:0032968

GO:0032991

GO:0036211

GO:0043226

GO:0044828

GO:0045737

GO:0050790

GO:0051301

GO:0061575

GO:0070816

GO:0098772

GO:0140096

GO:2001165

HMNXSV003001602

HMNXSV003041383

Hs.12186.1.A1_3p_at

ILMN_1689123

PH_hs_0033204

TC14000622.hg

TC14000623.hg

g4502624_3p_at

p4977

Participates

as a component of

as an input of

as an output of

TP53 stimulates CCNK expression (Homo sapiens)

as a member of

CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)

Inferred To

lsc1 [nucleoplasm] (Schizosaccharomyces pombe)

CCNK [nucleoplasm] (Bos taurus)

CCNK [nucleoplasm] (Canis familiaris)

CCNK [nucleoplasm] (Dictyostelium discoideum)

CCNK [nucleoplasm] (Gallus gallus)

CCNK [nucleoplasm] (Sus scrofa)

ccnk [nucleoplasm] (Danio rerio)

ccnk [nucleoplasm] (Xenopus tropicalis)

pch1 [nucleoplasm] (Schizosaccharomyces pombe)

ccnk-1 [nucleoplasm] (Caenorhabditis elegans)

Ccnk [nucleoplasm] (Mus musculus)

Ccnk [nucleoplasm] (Rattus norvegicus)

BUR2 [nucleoplasm] (Saccharomyces cerevisiae)

CTK2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CCNK [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CCNK [nucleoplasm] (Schizosaccharomyces pombe)

CycK [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001092872.1, XP_005268211.1, XP_011535577.1

OpenTargets

ENSG00000090061

HPA

ENSG00000090061-CCNK

GeneCards

O75909

Ensembl

ENSG00000090061, ENSP00000374529, ENST00000389879

PRO

O75909

Pharos - Targets

O75909

PDB

7NXK, 5ACB, 6CKX, 6TD3, 4UN0, 5EFQ, 6B3E, 4NST, 4CXA, 7NXJ, 2I53

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14004 CDK13	3	CDK13 [nucleoplasm] (R-HSA-6797014) CDK13 [extracellular region] (R-HSA-6806442) CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374)	0.71	7
UniProt:Q93062 RBPMS			0.666	4
UniProt:Q9NYV4 CDK12	1	CDK12 [nucleoplasm] (R-HSA-6797012)	0.59	4
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:O14777 NDC80	1	NDC80 [cytosol] (R-HSA-375314)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P54253 ATX1			0.508	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.462	2

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