Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes that are downregulated by STAT3 include the extracellular protein Tumor necrosis factor ligand superfamily member 6 (FASLG) (Ivanov et al. 2001).
Ivanov, VN, Bhoumik, A, Krasilnikov, M, Raz, R, Owen-Schaub, LB, Levy, D, Horvath, CM, Ronai, Z
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