Expression of HSPA8, ALOX15

Stable Identifier
R-HSA-6797269
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of HSPA8, ALOX15
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In human peripheral blood monocytes Interleukin-4 (IL4) and IL13 significantly upregulate the levels of proteins involved in inflammatory resolution including the cytoplasmic proteins 15-lipoxygenase (ALOX15) and heat shock protein 8 (HSP8) (Chaitidis et al. 2005, Yakubenko et al. 2011).

Literature References
PubMed ID Title Journal Year
15869882 Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13

Chaitidis, P, Bermudez-Fajardo, A, Kuban, RJ, O'Donnell, V, Kühn, H, Ungethuem, U

Cytokine 2005
21252155 αMßâ‚‚ integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formation

Yakubenko, VP, Cathcart, MK, Bhattacharjee, A, Pluskota, E

Circ. Res. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
IL4, IL13 [extracellular region] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-09-07)
Cite Us!