Reactome | LRPP4(LRPP1-3,5) hydrolyse LPA

LRPP4(LRPP1-3,5) hydrolyse LPA

Stable Identifier

R-HSA-6797630

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Human plasticity-related genes (PRGs, lipid phosphate phosphatase-related proteins LPPRs) comprise 5 members expressed in the CNS. They are membrane-spanning enzymes thought to mediate the extracellular concentration and signal transduction of lipid phosphate esters such as lysophosphatidic acid (LPA) and spingosine-1 phosphate (S1P) by hydrolysing their phosphate groups. LPPR4 has been shown to act as an ecto-enzyme in axon growth and regenerative sprouting by mediating LPA levels (Brauer et al. 2003). The activity of the other LPPR members has yet to be defined (Strauss & Brauer 2013).

Literature References

PubMed ID	Title	Journal	Year
12730698	A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting Nitsch, R, Savaskan, NE, Kühn, H, Bräuer, AU, Ninnemann, O, Prehn, S	Nat. Neurosci.	2003
23388400	Current views on regulation and function of plasticity-related genes (PRGs/LPPRs) in the brain Bräuer, AU, Strauss, U	Biochim. Biophys. Acta	2013