Reactome | ALDH7A1 oxidises BETALD to BET

ALDH7A1 oxidises BETALD to BET

Stable Identifier

R-HSA-6797955

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) is a multifunctional enzyme present in mitochondria, nucleus and the cytosol and plays an important role in protecting against hyperosmotic stress and metabolising toxic aldehydes. It is able to oxidise the osmolyte precursor betaine aldehyde (BETALD) to betaine (BET) (as well as the intermediate lysine degradation product, alpha-aminoadipic semialdehyde, not shown here) (Brocker et al. 2010). The mitochondrial isoform of ALDH7A1 is shown here.

Literature References

PubMed ID	Title	Journal	Year
20207735	Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress Lassen, N, Pappa, A, Chavakis, T, Brocker, C, Orlova, VV, Oppermann, U, Cantore, M, Vasiliou, V, Kavanagh, KL, Estey, T	J. Biol. Chem.	2010