TP53 family members stimulate CASP1 expression

Stable Identifier
R-HSA-6798081
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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TP53 family members stimulate CASP1 expression
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Upon binding to the p53 response element in the promoter of the caspase-1 (CASP1) gene, TP53 (p53), TP63 (p63) or TP73 (p73) stimulates transcription of CASP1 (Gupta et al. 2001, Jain et al. 2005, Celardo et al. 2013). CASP1 acts as the interleukin-1 beta (IL1B) converting enzyme (Cerretti et al. 1992) and is involved in the inflammation-related cell death - pyroptosis (Miura et al. 1993, Brough and Rothwell 2007).
Literature References
PubMed ID Title Journal Year
8242741 Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

Hartwieg, EA, Rotello, R, Zhu, H, Yuan, J, Miura, M

Cell 1993
16135520 Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin

Gupta, S, Radha, V, Jain, N, Swarup, G, Sudhakar, Ch

J. Biol. Chem. 2005
11278253 Direct transcriptional activation of human caspase-1 by tumor suppressor p53

Furukawa, Y, Swarup, G, Gupta, S, Radha, V

J. Biol. Chem. 2001
23703390 Caspase-1 is a novel target of p63 in tumor suppression

Grespi, F, Celardo, I, Bernassola, F, Garabadgiu, AV, Antonov, A, Amelio, I, Melino, G

Cell Death Dis 2013
1373520 Molecular cloning of the interleukin-1 beta converting enzyme

Greenstreet, TA, Kronheim, SR, Van Ness, K, Mosley, B, Cerretti, DP, Nelson, N, Cannizzaro, LA, March, CJ, Kozlosky, CJ, Druck, T

Science 1992
17284521 Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Rothwell, NJ, Brough, D

J Cell Sci 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
(p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53,TP63,TP73 [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-17)
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