Reactome | CASP6 (1-293) [cytosol]

CASP6 (1-293) [cytosol]

Stable Identifier

R-HSA-6798132

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9C004 SPY4

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        TP53 stimulates CASP6 expression (Homo sapiens)
        
        CASP6 (1-293) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55212 CASP6

Gene Names

CASP6, MCH2

Chain

propeptide:1-23, chain:24-179, propeptide:180-193, chain:194-293

Reference Genes

BioGPS Gene:839 CASP6

COSMIC (genes):CASP6 CASP6

CTD Gene:839 CASP6

dbSNP Gene:839 CASP6

ENSEMBL:ENSG00000138794 CASP6

ENSEMBL_homo_sapiens_GENE:ENSG00000138794.10 CASP6

HGNC:1507 CASP6

KEGG Gene (Homo sapiens):839 CASP6

Monarch:839 CASP6

NCBI Gene:839 CASP6

OMIM:601532 CASP6

UCSC:P55212 CASP6

Reference Transcript

Other Identifiers

11736215_x_at

16978959

209790_3p_s_at

209790_PM_s_at

209790_s_at

211464_3p_x_at

211464_PM_x_at

211464_x_at

2781694

2781695

2781696

2781697

2781701

2781702

2781703

2781704

2781705

2781709

2781710

35662_at

8102311

839

A_23_P500799

GE59001

GO:0002218

GO:0002376

GO:0003824

GO:0004175

GO:0004197

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0006915

GO:0008233

GO:0008234

GO:0012501

GO:0016540

GO:0016787

GO:0023052

GO:0030154

GO:0030855

GO:0042802

GO:0043065

GO:0043067

GO:0043226

GO:0048856

GO:0051604

GO:0051716

GO:0060545

GO:0070269

GO:0072332

GO:0072734

GO:0097153

GO:0097194

GO:0097200

GO:0097284

GO:0098542

GO:0140096

HMNXSV003001156

ILMN_1659350

ILMN_1694877

ILMN_2367113

PH_hs_0000401

TC04001464.hg

U20536_s_at

g12653078_3p_a_at

g12653078_3p_x_at

g882255_3p_a_at

g882255_3p_x_at

Participates

as an output of

TP53 stimulates CASP6 expression (Homo sapiens)

Other forms of this molecule

CASP6(194-293) [nucleoplasm]

CASP6(24-179) [nucleoplasm]

CASP6(24-179) [cytosol]

CASP6(194-293) [cytosol]

Cross References

RefSeq

NP_001217.2, NP_116787.1

Guide to Pharmacology - Targets

1622

OpenTargets

ENSG00000138794

HPA

ENSG00000138794-CASP6

ZINC - Substances

CASP6_HUMAN

GeneCards

P55212

ZINC target

P55212

Ensembl

ENST00000265164, ENST00000352981, ENSP00000265164, ENSG00000138794, ENSP00000285333

PRO

P55212

Pharos - Targets

P55212

ZINC - Predictions - Purchasable

CASP6_HUMAN

PDB

4N5D, 4NBL, 3NKF, 3NR2, 3K7E, 2WDP, 8F99, 4NBN, 4FXO, 8F97, 8F98, 4EJF, 3V6L, 4HVA, 4N6G, 3P45, 3V6M, 8F78, 8F96, 4NBK, 8F9D, 3S70, 6DEV, 3S8E, 4N7M, 3P4U, 3OD5, 8F9C, 4IYR, 6DEU, 4N7J, 8F9B, 3QNW, 8F9A, 8EG5, 8EG6, 8FBV

Interactors (216)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.865	8
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.571	2
UniProt:Q5JUW0-3 KRBOX4			0.556	3
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.556	3
UniProt:O60479 DLX3			0.556	3
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.556	3
UniProt:P20807-4 CAPN3			0.556	3
UniProt:Q92782-2 Q927822			0.556	3
UniProt:Q86V28 Q86V28			0.556	3
UniProt:Q6PJW8-3 Q6PJW83			0.556	3
UniProt:Q96C03-3 MIEF2			0.556	3
UniProt:Q8N6M8-2 Q8N6M82			0.556	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q9NTN9-3 SEMA4G			0.556	3
UniProt:A2RUH7 MBPHL			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q9Y614 ACL7B			0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q96BR5 COA7			0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:Q49A26-4 GLYR1			0.556	3
UniProt:P0DPB6 RPAC2			0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	3
UniProt:Q9NNX6-10 CD209			0.556	3
UniProt:Q9H0W9-3 C11ORF54			0.556	3
UniProt:Q5R372-9 RABGAP1L			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:Q8N1A6 CD033			0.556	3
UniProt:P54619 PRKAG1	2	PRKAG1 [nucleoplasm] (R-HSA-2151202) PRKAG1 [cytosol] (R-HSA-380946)	0.556	3
UniProt:P0C870 JMJD7	1	JMJD7 [cytosol] (R-HSA-9629577)	0.556	3
UniProt:Q9BV20 MRI1	1	MRI1 [cytosol] (R-HSA-1237095)	0.556	3
UniProt:Q49AJ0-4 Q49AJ04			0.556	3
UniProt:Q8NDH3-5 NPEPL1			0.556	3
UniProt:Q9UGL9 CRCT1			0.556	3
UniProt:Q6NXG1-3 Q6NXG13			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:Q5JTY5 ZNG1C			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P48739 PITPNB	2	PITPNB [endoplasmic reticulum membrane] (R-HSA-1524106) PITPNB [Golgi membrane] (R-HSA-1524113)	0.556	3
UniProt:Q9NRZ9-6 HELLS			0.556	3
UniProt:Q8WW27 APOBEC4	1	APOBEC4 [nucleoplasm] (R-HSA-8875000)	0.556	3
UniProt:P47804-3 P478043			0.556	3
UniProt:Q8N365 CIART			0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:O60927 PP1RB			0.556	3
UniProt:Q8TBB5-2 Q8TBB52			0.556	3
UniProt:Q8IWT0-2 ZBTB8OS			0.556	3
IntAct:EBI-25834490 CCSB			0.556	3
UniProt:Q9UJ70-2 NAGK			0.556	3
UniProt:Q9BRK5 CAB45			0.556	3
UniProt:P0DP58-2 LYNX1			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q53TN4 CYBRD1	1	CYBRD1 [plasma membrane] (R-HSA-917788)	0.556	3
IntAct:EBI-25835814 CCSB			0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
IntAct:EBI-25836220 CCSB			0.556	3
UniProt:Q16609 LPAL2			0.556	3
UniProt:Q5W111-2 SPRYD7			0.556	3
UniProt:Q9H8K7 PAAT			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q494V2-2 CFAP100			0.556	3
UniProt:Q9NX94 WBP1L			0.556	3
UniProt:Q9UIK5-2 Q9UIK52			0.556	3
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.556	3
UniProt:P26998 CRBB3			0.556	3
UniProt:O43548 TGM5	1	TGM5 [plasma membrane] (R-HSA-6814176)	0.556	3
UniProt:Q9BZQ2 SHP1L			0.556	3
UniProt:Q8WUD1-2 Q8WUD12			0.556	3
UniProt:Q66K80 RUAS1			0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q13347 EIF3I	1	EIF3I [cytosol] (R-HSA-72536)	0.556	3
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.556	3
UniProt:Q9H7X0 NAA60			0.556	3
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.556	3
UniProt:Q9NU02 ANKE1			0.556	3
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.556	3
UniProt:Q3SXR2 CC036			0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:A0A384MDV8 A0A384MDV8			0.556	3
UniProt:Q96A09 TET5B			0.556	3
UniProt:Q53NU3 Q53NU3			0.556	3
UniProt:Q8NCQ7-2 Q8NCQ72			0.556	3
UniProt:Q7Z3B4 NUP54	2	NUP54 [cytosol] (R-HSA-9634221) NUP54 [nuclear envelope] (R-HSA-157724)	0.556	3
UniProt:Q9NQ89 FERY3			0.556	3
UniProt:P09525 ANXA4			0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q9UK76 JUPI1			0.556	3
UniProt:Q96JB6 LOXL4	3	LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.556	3
UniProt:A0A0A0MR05 A0A0A0MR05			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
IntAct:EBI-25834975 CCSB			0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q96Q83-2 ALKBH3			0.556	3
UniProt:Q8N0U6 CF218			0.556	3
IntAct:EBI-25834617 CCSB			0.556	3
UniProt:P06276 BCHE	2	BCHE [extracellular region] (R-HSA-434469) BCHE [plasma membrane] (R-HSA-3640835)	0.556	3
IntAct:EBI-25835824 RZPDO834E0719D			0.556	3
UniProt:Q5T2L2 AKCL1			0.556	3
UniProt:P22307-3 P223073			0.556	3
UniProt:Q7Z6I5 SPT12			0.556	3
UniProt:Q9BT25 HAUS8	1	HAUS8 [cytosol] (R-HSA-8855198)	0.556	3
UniProt:Q496A3 SPAS1			0.556	3
UniProt:Q96EY1-3 DNAJA3			0.556	3
UniProt:Q96Q07-2 BTBD9			0.556	3
UniProt:P01011 SERPINA3	4	SERPINA3 [platelet alpha granule lumen] (R-HSA-8848913) SERPINA3 [secretory granule lumen] (R-HSA-6801018) SERPINA3 [extracellular region] (R-HSA-6806173) SERPINA3 [azurophil granule lumen] (R-HSA-6798754)	0.556	3
UniProt:Q58EX7-2 Q58EX72			0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
UniProt:B7Z3E8 B7Z3E8			0.556	3
IntAct:EBI-25836264 CCSB			0.556	3
UniProt:Q8N5J2-3 MINDY1			0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:P02458-1 COL2A1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:Q658K8 EF1DL			0.556	3
UniProt:Q9UKG9-2 Q9UKG92			0.556	3
UniProt:O60902-3 SHOX2			0.556	3
UniProt:Q99447 PCYT2	1	PCYT2 [endoplasmic reticulum membrane] (R-HSA-1498781)	0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:Q1L5Z9 LONF2			0.556	3
UniProt:P06727 APOA4	5	APOA4 [early endosome] (R-HSA-2429647) APOA4 [cytosol] (R-HSA-2395773) APOA4 [endoplasmic reticulum lumen] (R-HSA-174667) APOA4 [extracellular region] (R-HSA-174701) APOA4(21-94) [extracellular region] (R-HSA-976882)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:P49459 UBE2A	3	UBE2A [cytosol] (R-HSA-947617) Ub-C88-UBE2A [nucleoplasm] (R-HSA-8864186) UBE2A [nucleoplasm] (R-HSA-8852048)	0.556	3
UniProt:Q8N128-2 FAM177A1			0.556	3
UniProt:Q6IN84-2 MRM1			0.556	3
UniProt:Q8N5U6 RNF10			0.556	3
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.556	3
UniProt:Q15382 RHEB	2	RHEB [endosome membrane] (R-HSA-5656350) RHEB [lysosomal membrane] (R-HSA-165190)	0.556	3
UniProt:Q8IYG6 LRC56			0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.556	3
UniProt:P27815-4 PDE4A			0.556	3
UniProt:Q9Y303-2 AMDHD2			0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
UniProt:Q8N4N3-2 KLHL36			0.556	3
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.556	3
UniProt:Q14181 POLA2	1	POLA2 [nucleoplasm] (R-HSA-68493)	0.556	3
UniProt:Q9UH77 KLHL3	1	KLHL3 [cytosol] (R-HSA-8863198)	0.556	3
IntAct:EBI-25835866 CCSB			0.556	3
UniProt:Q3KNS6-3 Q3KNS63			0.556	3
UniProt:O00423 EMAL1			0.556	3
UniProt:O00303 EIF3F	1	EIF3F [cytosol] (R-HSA-72540)	0.556	3
UniProt:Q8NA23-2 Q8NA232			0.556	3
UniProt:Q3SX64 CMA1D			0.556	3
IntAct:EBI-25836274 CCSB			0.556	3
UniProt:Q92797-2 Q927972			0.556	3
UniProt:Q9NSA1 FGF21	2	FGF21 [cytosol] (R-HSA-6784692) FGF21 [extracellular region] (R-HSA-189909)	0.556	3
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.556	3
UniProt:P17655 CAPN2	2	CAPN2 [plasma membrane] (R-HSA-8863405) CAPN2 [cytosol] (R-HSA-8848630)	0.556	3
UniProt:Q15742-2 Q157422			0.556	3
UniProt:Q9BPU6 DPYSL5	3	p-Y-DPYSL5 [cytosol] (R-HSA-399786) DPYSL5 [cytosol] (R-HSA-398138) p-S534-DPYSL5 [cytosol] (R-HSA-399793)	0.556	3
UniProt:Q9NR46 SHLB2			0.556	3
UniProt:Q9HAV0 GNB4	4	GNB4 [plasma membrane] (R-HSA-164326) Unfolded GNB4 [cytosol] (R-HSA-6814201) Partially folded GNB4 [cytosol] (R-HSA-8850525) GNB4 [cytosol] (R-HSA-6814417)	0.556	3
IntAct:EBI-25835770 CCSB			0.556	3
UniProt:P36639-4 NUDT1	1	NUDT1-4 [cytosol] (R-HSA-2395813)	0.556	3
UniProt:P27338 MAOB	1	MAOB [mitochondrial outer membrane] (R-HSA-141194)	0.556	3
UniProt:Q6ZNL6 FGD5	1	FGD5 [cytosol] (R-HSA-9714447)	0.556	3
UniProt:O00257-3 CBX4			0.556	3
UniProt:Q9P1Q0-4 VPS54			0.556	3
UniProt:Q6N063-2 Q6N0632			0.556	3
UniProt:Q05CR2 Q05CR2			0.556	3
UniProt:Q6NXT2 H3C			0.556	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:A6NJ78-4 METTL15			0.556	3
IntAct:EBI-25835760 CCSB			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.556	3
UniProt:P09496-2 CLTA			0.556	3
UniProt:P34949-2 P349492			0.556	3
UniProt:Q8N1A0 KT222			0.556	3
UniProt:Q969L2 MAL2			0.556	3
UniProt:Q92613 JADE3	1	PHF16 [nucleoplasm] (R-HSA-3321851)	0.556	3
UniProt:P61925 IPKA			0.556	3
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.556	3
IntAct:EBI-25835796 CCSB			0.556	3
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.556	3
UniProt:P36954 POLR2I	1	POLR2I [nucleoplasm] (R-HSA-63525)	0.556	3
UniProt:Q9C004 SPY4			0.556	3
UniProt:Q9HD47-3 RANGRF			0.556	3
UniProt:P54687-4 P546874			0.556	3
UniProt:Q9BUL5 PHF23			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:Q8NFH3 NUP43	2	NUP43 [nuclear envelope] (R-HSA-157739) NUP43 [cytosol] (R-HSA-376243)	0.556	3
UniProt:Q8NFH4 NUP37	2	NUP37 [nuclear envelope] (R-HSA-157745) NUP37 [cytosol] (R-HSA-376237)	0.556	3
UniProt:Q96EW2-2 Q96EW22			0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.556	3
UniProt:Q96MA6 AK8	1	AK8 [cytosol] (R-HSA-6788788)	0.556	3
UniProt:Q96JL9-2 Q96JL92			0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.556	3
UniProt:Q99966 CITED1	1	CITED1 [nucleoplasm] (R-HSA-8864301)	0.556	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.556	3
UniProt:Q9NQ88 TIGAR	1	TIGAR [cytosol] (R-HSA-5628829)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q00169 PITPNA	1	PITPNA [cytosol] (R-HSA-418391)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:Q14032 BAAT	2	BAAT [cytosol] (R-HSA-159392) BAAT [peroxisomal matrix] (R-HSA-193517)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.556	3
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.556	3

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