Choline catabolism

Stable Identifier
R-HSA-6798163
DOI
10.3180/R-HSA-6798163.3
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Choline catabolism
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Choline is an essential water-soluble nutrient in humans, serving as a precursor of phospholipids and the neurotransmitter acetylcholine. It is often associated with B vitamins based on its chemical structure but it isn't an official B vitamin. Its oxidation to betaine provides a link to folate-dependent, one-carbon metabolism where betaine is a methyl donor in the methionine cycle. Betaine is further metabolised to dimethylglycine which is cleared by the kidney (Ueland 2011, Hollenbeck 2012).
Literature References
PubMed ID Title Journal Year
22483274 An introduction to the nutrition and metabolism of choline

Hollenbeck, CB

Cent Nerv Syst Agents Med Chem 2012
20446114 Choline and betaine in health and disease

Ueland, PM

J. Inherit. Metab. Dis. 2011
Participants
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Event Information
Go Biological Process
choline catabolic process (0042426)
Orthologous Events
Choline catabolism (Bos taurus)
Choline catabolism (Caenorhabditis elegans)
Choline catabolism (Canis familiaris)
Choline catabolism (Danio rerio)
Choline catabolism (Dictyostelium discoideum)
Choline catabolism (Drosophila melanogaster)
Choline catabolism (Gallus gallus)
Choline catabolism (Mus musculus)
Choline catabolism (Plasmodium falciparum)
Choline catabolism (Rattus norvegicus)
Choline catabolism (Sus scrofa)
Choline catabolism (Xenopus tropicalis)
Authored
Jassal, B  (2015-09-17)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-09-17)
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