GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC

Stable Identifier
R-HSA-6798317
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cytosolic glycine N-methyltransferase (GNMT) catalyses the transfer of a methyl group from S-adenosylmethionine (AdoMet) to glycine (Gly) to form sarcosine (SARC, aka N-methylglycine) with the concomitant production of S-adenosylhomocysteine (AdoHcy) (Pakhomova et al. 2004).
Literature References
PubMed ID Title Journal Year
15340920 Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes

Grohmann, S, Pakhomova, S, Luka, Z, Newcomer, ME, Wagner, C

Proteins 2004
Participants
Participates
Catalyst Activity

glycine N-methyltransferase activity of GNMT tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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