GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC

Stable Identifier
R-HSA-6798317
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC
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Cytosolic glycine N-methyltransferase (GNMT) catalyses the transfer of a methyl group from S-adenosylmethionine (AdoMet) to glycine (Gly) to form sarcosine (SARC, aka N-methylglycine) with the concomitant production of S-adenosylhomocysteine (AdoHcy) (Pakhomova et al. 2004).
Literature References
PubMed ID Title Journal Year
15340920 Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes

Grohmann, S, Pakhomova, S, Luka, Z, Newcomer, ME, Wagner, C

Proteins 2004
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Output
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as an event of
Catalyst Activity

glycine N-methyltransferase activity of GNMT tetramer [cytosol]

Physical Entity
GNMT tetramer [cytosol] (Homo sapiens)
Activity
glycine N-methyltransferase activity (GO:0017174)
Orthologous Events
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Danio rerio)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Drosophila melanogaster)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Sus scrofa)
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-09-18)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-09-18)
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