Reactome | GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC

GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC

Stable Identifier

R-HSA-6798317

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

glycine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sarcosine

ReviewStatus

5/5

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GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC

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Cytosolic glycine N-methyltransferase (GNMT) catalyses the transfer of a methyl group from S-adenosylmethionine (AdoMet) to glycine (Gly) to form sarcosine (SARC, aka N-methylglycine) with the concomitant production of S-adenosylhomocysteine (AdoHcy) (Pakhomova et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15340920	Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes Pakhomova, S, Luka, Z, Grohmann, S, Wagner, C, Newcomer, ME	Proteins	2004