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BPGM dimer isomerises 1,3BPG to 2,3BPG
Stable Identifier
R-HSA-6798335
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific trifunctional enzyme. One of its functions is the isomerisation of 1,3-bisphosphoglycerate (1,3BPG) to 2,3-bisphosphoglycerate (2,3BPG) (Rose 1968). In red blood cells, 2,3BPG is the main allosteric effector of hemoglobin, binding preferentially to the deoxygenated hemoglobin tetramer, thus reducing oxygen affinity (Arnone 1972).
Literature References
PubMed ID
Title
Journal
Year
5687724
The purification and properties of diphosphoglycerate mutase from human erythrocytes
Rose, ZB
J. Biol. Chem.
1968
4555506
X-ray diffraction study of binding of 2,3-diphosphoglycerate to human deoxyhaemoglobin
Arnone, A
Nature
1972
Participants
Input
1,3BPG [cytosol]
Output
2,3BPG [cytosol]
Participates
as an event of
Glycolysis (Homo sapiens)
Event Information
Go Biological Process
carbohydrate derivative catabolic process (1901136)
Catalyst Activity
bisphosphoglycerate mutase activity of BPGM dimer [cytosol]
Physical Entity
BPGM dimer [cytosol]
(Homo sapiens)
Activity
bisphosphoglycerate mutase activity (GO:0004082)
Orthologous Events
BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Canis familiaris)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Gallus gallus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Rattus norvegicus)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Schizosaccharomyces pombe)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)
BPGM dimer isomerises 1,3BPG to 2,3BPG (Xenopus tropicalis)
Authored
Jassal, B (2015-09-18)
Reviewed
D'Eustachio, P (2016-01-11)
Created
Jassal, B (2015-09-18)
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