Reactome | ATM phosphorylates DYRK2

ATM phosphorylates DYRK2

Stable Identifier

R-HSA-6798372

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATM phosphorylates DYRK2 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated ATM kinase phosphorylates DYRK2 at threonine residue T106 (matching T33 in the shorter splicing isoform of DYRK2) and serine residue S442 (matching S369 in the shorter splicing isoform of DYRK2). ATM-mediated phosphorylation of DYRK2 prevents DYRK2 ubiquitination by MDM2 and the consequent DYRK2 degradation (Taira et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19965871	ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage Yamamoto, H, Miki, Y, Taira, N, Yoshida, K, Yamaguchi, T	J. Biol. Chem.	2010