Reactome | RPS18 [nucleoplasm]

RPS18 [nucleoplasm]

Stable Identifier

R-HSA-6798701

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S small ribosomal protein 18, P25232, 40S ribosomal protein S18, KE-3, KE3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62269 RPS18

Gene Names

RPS18, D6S218E

Chain

initiator methionine:, chain:2-152

Reference Genes

BioGPS Gene:6222 RPS18

COSMIC (genes):RPS18 RPS18

CTD Gene:6222 RPS18

dbSNP Gene:6222 RPS18

ENSEMBL:ENSG00000231500 RPS18

HGNC:10401 RPS18

KEGG:hsa:6222 RPS18

Monarch:6222 RPS18

NCBI Gene:6222 RPS18

OMIM:180473 RPS18

UCSC:P62269 RPS18

Reference Transcript

RefSeq:NM_022551.2 RPS18

Other Identifiers

11756437_x_at

11762344_at

17007426

17028475

17031289

17036038

17038759

17041345

17041350

201049_PM_s_at

201049_s_at

2686718

2686719

2686720

2686721

2686724

2903558

2903559

2903560

2903561

2903562

2903564

2903565

2903566

2903567

2903568

2903569

2903570

2903571

2903572

2903573

2903575

2903576

2930816

31545_at

3548492

3746486

6222

8118644

8178253

8179544

A_14_P121071

A_23_P214666

GE508175

GO:0002181

GO:0003676

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005581

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0014069

GO:0015935

GO:0016020

GO:0019843

GO:0022626

GO:0022627

GO:0043226

GO:0045202

GO:0070062

GO:1990904

HMNXSV003042648

ILMN_1753534

PH_hs_0029574

TC06000417.hg

TC06002737.hg

TC6_cox_hap2000107.hg

TC6_dbb_hap3000099.hg

TC6_mcf_hap5000092.hg

TC6_qbl_hap6000098.hg

TC6_ssto_hap7000088.hg

TC6_ssto_hap7000089.hg

X69150_at

g11968181_3p_a_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPS18 [cytosol]

Inferred To

Ghost homologue of RPS18 [nucleoplasm] (Gallus gallus)

RPS18A [nucleoplasm] (Saccharomyces cerevisiae)

RPS18 [nucleoplasm] (Bos taurus)

RPS18 [nucleoplasm] (Canis familiaris)

RPS18 [nucleoplasm] (Plasmodium falciparum)

RPS18 [nucleoplasm] (Sus scrofa)

rps1802 [nucleoplasm] (Schizosaccharomyces pombe)

rps-18 [nucleoplasm] (Caenorhabditis elegans)

RpS18 [nucleoplasm] (Drosophila melanogaster)

Homologues of RPS18 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RPS18 [nucleoplasm] (Schizosaccharomyces pombe)

rps1801 [nucleoplasm] (Schizosaccharomyces pombe)

Rps18 [nucleoplasm] (Mus musculus)

Rps18 [nucleoplasm] (Rattus norvegicus)

RPS18B [nucleoplasm] (Saccharomyces cerevisiae)

rps18 [nucleoplasm] (Danio rerio)

rps18 [nucleoplasm] (Dictyostelium discoideum)

rps18 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_072045.1

OpenTargets

ENSG00000231500

ENSEMBL

ENST00000457341, ENSP00000416110, ENSP00000393241, ENST00000454021, ENSP00000412583, ENSP00000403175, ENST00000211372, ENSP00000211372, ENST00000439602, ENST00000434122

HPA

ENSG00000231500-RPS18

PRO

P62269

Pharos - Targets

P62269

GlyGen

P62269

PDB

5AJ0, 8G5Y, 7K5I, 6ZXH, 6OLF, 7R4X, 6OM7, 8JDL, 6Y2L, 6QZP, 6Y57, 5T2C, 8GLP, 5OA3, 6ZUO, 6ZLW, 6ZM7, 6XA1, 6IP5, 6IP8, 6ZON, 7QP6, 6ZOJ, 6ZMO, 6Z6M, 6OLI, 8XXM, 4V6X, 6Z6L, 8IFD, 6ZV6, 6ZMW, 4UG0, 6OLZ, 6ZMI, 7XNX, 6G51, 6OM0, 5VYC, 8G60, 8QOI, 6G18, 6ZN5, 8PPL, 7WTT, 8XXN, 6ZXG, 6ZXF, 8PPK, 8IFE, 6ZVJ, 8JDJ, 5LKS, 8G6J, 6ZME, 5FLX, 6ZXE, 6ZXD, 6G5H, 6G5I, 6ZP4, 7TQL, 8OZ0, 6FEC, 7A09, 6IP6, 6YBS, 6ZOL, 7WU0, 7QP7, 6Y0G, 6G4W, 6G53, 8T4S, 6ZVH, 7WTZ, 6Z6N, 7WTX, 7XNY, 8JDK, 8JDM, 6OLE, 8G61, 6G4S, 5A2Q, 8XXL, 6ZMT, 6OLG, 7WTU, 7WTW, 8Y0X, 7WTV, 8Y0W

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.715	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12

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