Reactome | RPSA [nucleoplasm]

RPSA [nucleoplasm]

Stable Identifier

R-HSA-6798722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S small ribosomal protein P4, P08865, 40S ribosomal protein SA, P40, 34/67 kDa laminin receptor, Colon carcinoma laminin-binding protein, NEM/1CHD4, Multidrug resistance- associated protein MGr1-Ag

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08865 RPSA

Gene Names

RPSA, LAMBR, LAMR1

Chain

initiator methionine:1, chain:2-295

Reference Genes

BioGPS Gene:3921 RPSA

COSMIC (genes):RPSA RPSA

CTD Gene:3921 RPSA

dbSNP Gene:3921 RPSA

ENSEMBL:ENSG00000168028 RPSA

HGNC:6502 RPSA

KEGG:hsa:3921 RPSA

Monarch:3921 RPSA

NCBI Gene:3921 RPSA

OMIM:150370 RPSA

UCSC:P08865 RPSA

Reference Transcript

Other Identifiers

11757119_at

11757128_at

11757305_x_at

16939419

17119340

213801_PM_x_at

213801_x_at

2425627

2425629

2425631

2425633

2425635

2425637

2425641

2425643

2425645

2436651

2436653

2440102

2440114

2440116

2484817

2484822

2484823

256_s_at

2615859

2618292

2618294

2618296

2618298

2618300

2618302

2618304

2618306

2618308

2618310

2618312

2618314

2618316

2618318

2618320

2618322

2618324

2618326

2618328

2618330

2618332

2618334

2618336

2618338

2618342

2618344

2618346

2688367

2713125

2733277

2745643

2970250

3064526

3104760

3175476

3175481

3175487

3175491

3178398

3225386

3461268

3480591

3480593

3480594

3480599

3516848

3549854

3572729

3827228

3827230

3827231

3827233

3827234

3827235

3827236

3827237

3921

3975436

3975438

3981817

4014396

4014397

4014399

4014402

4014403

59681_at

7918050

8078905

8078916

8078918

A_14_P101602

A_21_P0000235

A_21_P0010639

A_23_P254415

A_33_P3334448

GE80131

GO:0000028

GO:0001618

GO:0002181

GO:0003677

GO:0003723

GO:0003735

GO:0005055

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005886

GO:0006325

GO:0006338

GO:0006412

GO:0007155

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0043022

GO:0043236

GO:0046718

GO:0065003

GO:0070062

GO:0098631

GO:0140374

GO:1990904

HMNXSV003035555

HMNXSV003041550

HMNXSV003054833

Hs.181357.2.A1_3p_x_at

ILMN_1664910

ILMN_1700074

ILMN_2411723

M14199_s_at

PH_hs_0029924

PH_hs_0035860

RNA33429|snoRNA_scaRNA_24_154

RNA33432|snoRNA_scaRNA_27_149

TC01005671.hg

TC03000202.hg

TC03002295.hg

U43901_rna1_s_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPSA [cytosol]

RPSA [plasma membrane]

Inferred To

rps001 [nucleoplasm] (Schizosaccharomyces pombe)

sta [nucleoplasm] (Drosophila melanogaster)

Rpsa [nucleoplasm] (Mus musculus)

Rpsa [nucleoplasm] (Rattus norvegicus)

rps-0 [nucleoplasm] (Caenorhabditis elegans)

rpsA [nucleoplasm] (Dictyostelium discoideum)

rpsa [nucleoplasm] (Danio rerio)

rpsa [nucleoplasm] (Xenopus tropicalis)

RPSA [nucleoplasm] (Bos taurus)

RPSA [nucleoplasm] (Canis familiaris)

RPSA [nucleoplasm] (Sus scrofa)

RPS0A [nucleoplasm] (Saccharomyces cerevisiae)

RPS2 [nucleoplasm] (Plasmodium falciparum)

Cross References

RefSeq

NP_001291217.1, NP_002286.2

OpenTargets

ENSG00000168028

ENSEMBL

ENST00000697730, ENSP00000513424, ENSP00000410848, ENST00000697731, ENSP00000513425, ENST00000301821, ENST00000697729, ENST00000458478, ENSP00000513423, ENSP00000346067, ENSG00000168028

GeneCards

RPSA

HPA

ENSG00000168028-RPSA

PRO

P08865

Pharos - Targets

P08865

GlyGen

P08865

Orphanet

RPSA

PDB

8G6J, 8XSX, 6ZOK, 5FLX, 6G4S, 6Z6M, 6QZP, 8QOI, 7WTZ, 8ZDD, 5VYC, 6ZOJ, 3BCH, 7WTV, 6ZME, 8JDM, 6OLG, 6XA1, 6ZUO, 8XXM, 8PJ3, 4V6X, 8PJ4, 8PPK, 6ZXH, 6ZLW, 4V5Z, 9G8M, 9G8O, 6ZXE, 7QP7, 8IFE, 7XNY, 5LKS, 6IP5, 8RG0, 6ZON, 6ZVJ, 6Z6N, 6G53, 6ZMW, 6ZMI, 9C3H, 8T4S, 8K2C, 6Y2L, 5OA3, 8JDL, 8PJ6, 6OLE, 8Y0X, 8G61, 6Y0G, 8XXL, 7WU0, 8PJ2, 7R4X, 8XP3, 6ZXF, 9BLN, 8PJ1, 8YOP, 4UG0, 7QP6, 8IFD, 6IP6, 8XSZ, 6G51, 6Z6L, 6ZN5, 7WTX, 8ZDC, 6ZMO, 6G18, 6OM0, 8JDK, 6ZM7, 8G60, 6OLF, 6G5H, 7K5I, 8PPL, 8PJ5, 5AJ0, 8UKB, 6Y57, 6OLZ, 7TQL, 6ZXG, 8XP2, 6ZVH, 6ZP4, 6OM7, 7XNX, 8XSY, 5T2C, 6YBD, 6ZV6, 6ZMT, 8ZDB, 7WTW, 6YBW, 6OLI, 8G5Z, 8JDJ, 8G5Y, 6G5I, 8Y0W, 8XXN, 8GLP, 9BKD, 6FEC, 5A2Q, 7QVP, 7A09, 8OZ0, 8YOO, 6IP8, 6ZXD

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15046 KARS1	4	KARS [cytosol] (R-HSA-379568) p-S207 KARS [cytosol] (R-HSA-9825686) p-S207 KARS [nucleoplasm] (R-HSA-9825687) KARS [mitochondrial matrix] (R-HSA-379617)	0.765	9
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.666	4
UniProt:P63220 RPS21	2	RPS21 [cytosol] (R-HSA-72351) RPS21 [nucleoplasm] (R-HSA-6798732)	0.659	4
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P00441 SOD1	5	2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705)	0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:Q9UQC2 GAB2	5	p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y643-GAB2 [cytosol] (R-HSA-9677149)	0.556	3
UniProt:Q9Y2W7 KCNIP3	2	KCNIP3 [plasma membrane] (R-HSA-5577044) KCNIP3 [nucleoplasm] (R-HSA-9640052)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P0DTD1-PRO_0000449619 REP			0.528	3
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) RPS27A(1-76) [cytosol] (R-HSA-939205) p-S65-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834951) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834993) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-63-RPS27A(1-76) [plasma membrane] (R-HSA-939855)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:P08708 RPS17	2	RPS17 [cytosol] (R-HSA-72339) RPS17 [nucleoplasm] (R-HSA-6798719)	0.527	3
UniProt:P58317 ZN121			0.527	2
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	2
UniProt:Q6P158 DHX57			0.527	3
UniProt:Q15050 RRS1			0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:Q86X02 CDR2L			0.527	2
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.527	3
UniProt:Q01850 CDR2			0.527	2
UniProt:Q9BRU9 UTP23			0.527	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	2
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.527	3
UniProt:Q9NW07 ZN358			0.527	2
UniProt:Q96QR8 PURB			0.527	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:P62158 CALM			0.488	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12

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