Reactome | RPSA [nucleoplasm]

RPSA [nucleoplasm]

Stable Identifier

R-HSA-6798722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S small ribosomal protein P4, P08865, 40S ribosomal protein SA, P40, 34/67 kDa laminin receptor, Colon carcinoma laminin-binding protein, NEM/1CHD4, Multidrug resistance- associated protein MGr1-Ag

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08865 RPSA

Gene Names

RPSA, LAMBR, LAMR1

Chain

initiator methionine:, chain:2-295

Reference Genes

BioGPS Gene:3921 RPSA

COSMIC (genes):RPSA RPSA

CTD Gene:3921 RPSA

dbSNP Gene:3921 RPSA

ENSEMBL:ENSG00000168028 RPSA

ENSEMBL_homo_sapiens_GENE:ENSG00000168028.15 RPSA

HGNC:6502 RPSA

KEGG Gene (Homo sapiens):3921 RPSA

Monarch:3921 RPSA

NCBI Gene:3921 RPSA

OMIM:150370 RPSA

UCSC:P08865 RPSA

Reference Transcript

Other Identifiers

11757305_x_at

213801_PM_x_at

213801_x_at

2425627

2425629

2425631

2425633

2425635

2425637

2425641

2425643

2425645

2436651

2436653

2440102

2440114

2440116

2484817

2484822

2484823

256_s_at

2615859

2618292

2618294

2618298

2618306

2618312

2618314

2618316

2618326

2618328

2618330

2618334

2618336

2618338

2688367

2713125

2733277

2745643

2970250

3064526

3104760

3175476

3175481

3175487

3175491

3178398

3461268

3480591

3480593

3480594

3480599

3516848

3549854

3827228

3827230

3827231

3827233

3827234

3827235

3827236

3827237

3921

3975436

3975438

3981817

4014396

4014397

4014399

4014402

4014403

59681_at

7918050

8078905

A_21_P0010639

A_23_P254415

GE80131

GO:0000028

GO:0001618

GO:0002181

GO:0003723

GO:0003735

GO:0005055

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0007155

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0042254

GO:0043022

GO:0043226

GO:0043236

GO:0046718

GO:0065003

GO:0070062

GO:0098631

GO:0110165

GO:1990904

HMNXSV003035555

Hs.181357.2.A1_3p_x_at

ILMN_1664910

ILMN_2411723

M14199_s_at

PH_hs_0029924

PH_hs_0035860

TC01005671.hg

U43901_rna1_s_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPSA [cytosol]

Inferred To

rps001 [nucleoplasm] (Schizosaccharomyces pombe)

sta [nucleoplasm] (Drosophila melanogaster)

Rpsa [nucleoplasm] (Mus musculus)

Rpsa [nucleoplasm] (Rattus norvegicus)

rps-0 [nucleoplasm] (Caenorhabditis elegans)

rpsA [nucleoplasm] (Dictyostelium discoideum)

rpsa [nucleoplasm] (Danio rerio)

rpsa [nucleoplasm] (Xenopus tropicalis)

RPSA [nucleoplasm] (Bos taurus)

RPSA [nucleoplasm] (Canis familiaris)

RPSA [nucleoplasm] (Gallus gallus)

RPSA [nucleoplasm] (Plasmodium falciparum)

RPSA [nucleoplasm] (Sus scrofa)

RPS0A [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001291217.1, NP_002286.2

OpenTargets

ENSG00000168028

HPA

ENSG00000168028-RPSA

GeneCards

P08865

Ensembl

ENSP00000513425, ENSP00000513424, ENSP00000346067, ENSP00000410848, ENST00000458478, ENSP00000513423, ENST00000697729, ENST00000697730, ENST00000301821, ENSG00000168028, ENST00000697731

PRO

P08865

Pharos - Targets

P08865

Orphanet

22218

PDB

7WU0, 6ZXH, 5OA3, 7QVP, 6OLE, 6YBD, 7WTW, 6ZUO, 3BCH, 8G60, 6Y0G, 6G4S, 6ZXF, 7R4X, 7WTX, 7TQL, 6OM0, 8G5Z, 6XA1, 7K5I, 7XNY, 5FLX, 6IP6, 6FEC, 6ZXD, 8G5Y, 7QP7, 7WTV, 6ZXE, 7QP6, 6Z6L, 8GLP, 4UG0, 6ZVH, 6OLF, 6OLG, 5AJ0, 6ZMW, 6ZOJ, 8G6J, 7WTZ, 5LKS, 5VYC, 6ZMI, 5T2C, 6G53, 6ZV6, 6OM7, 6Y57, 6YBW, 8T4S, 6IP8, 6ZXG, 6ZP4, 6Y2L, 6ZME, 4V6X, 6G18, 8G61, 6OLZ, 6G51, 6QZP, 6G5H, 6IP5, 6Z6N, 6ZM7, 6ZOK, 6ZVJ, 6G5I, 6ZN5, 5A2Q, 6OLI, 7A09, 6ZON, 6ZMO, 6ZMT, 6ZLW, 7XNX, 6Z6M

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.666	4
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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