ATM phosphorylates ZNF420

Stable Identifier
R-HSA-6799097
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activated ATM phosphorylates ZNF420 (Apak) at serine residue S68. Phosphorylation at S68 inhibits ZNF420 binding to the first intron of TP53AIP1 (p53AIP1) gene, thus facilitating TP53 (p53)-mediated expression of TP53AIP1 (Yuan et al. 2012). ATM-mediated phosphorylation of ZNF420 also inhibits ZNF420 interaction with TP53 and the consequent TP53 deacetylation (Tian et al. 2009).
Literature References
PubMed ID Title Journal Year
19377469 KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis

Tian, C, Li, L, Wang, J, Nie, J, Xing, G, Gao, M, Lu, K, Xie, P, He, F, Zhang, L

Nat. Cell Biol. 2009
22334068 Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis

Tian, C, Wang, H, Song, S, Xing, G, Yin, Y, He, F, Li, D, Yuan, L, Zhang, L

EMBO Rep. 2012
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Orthologous Events
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