Reactome | FTL [azurophil granule lumen]

FTL [azurophil granule lumen]

Stable Identifier

R-HSA-6799149

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Ferritin light chain, FRIL_HUMAN

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External Reference Information

External Reference

UniProt:P02792 FTL

Gene Names

FTL

Chain

initiator methionine:, chain:2-175

Reference Genes

BioGPS Gene:2512 FTL

COSMIC (genes):FTL FTL

CTD Gene:2512 FTL

dbSNP Gene:2512 FTL

ENSEMBL:ENSG00000087086 FTL

ENSEMBL_homo_sapiens_GENE:ENSG00000087086.15 FTL

HGNC:3999 FTL

KEGG Gene (Homo sapiens):2512 FTL

Monarch:2512 FTL

NCBI Gene:2512 FTL

OMIM:134790 FTL

UCSC:P02792 FTL

Reference Transcript

RefSeq:NM_000146.3 FTL

Other Identifiers

11755280_x_at

11757269_s_at

11757326_s_at

11757327_x_at

11757346_s_at

11757728_s_at

11757787_x_at

11758182_x_at

16863939

212788_PM_x_at

212788_x_at

213187_PM_x_at

213187_x_at

2512

35083_at

3838095

3838096

3838097

3838099

3838102

3838104

3838105

3838106

3838107

3838108

3874609

3874610

3874611

3972940

43423_s_at

8030171

A_23_P50498

A_23_P50504

GO:0005506

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0006826

GO:0006879

GO:0006880

GO:0008043

GO:0008198

GO:0008199

GO:0016020

GO:0031410

GO:0035578

GO:0042802

GO:0043226

GO:0044754

GO:0046872

GO:0055065

GO:0070062

HMNXSV003057940

Hs.111334.1.S1_3p_a_at

Hs.324746.2.S1_3p_s_at

ILMN_1740429

ILMN_1814823

M11147_at

TC19000717.hg

TC19002195.hg

TC20000047.hg

g7662555_3p_x_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

FTL [cytosol]

FTL [endocytic vesicle lumen]

FTL [extracellular region]

Inferred To

FTL [azurophil granule lumen] (Bos taurus)

FTL [azurophil granule lumen] (Caenorhabditis elegans)

FTL [azurophil granule lumen] (Canis familiaris)

FTL [azurophil granule lumen] (Mus musculus)

FTL [azurophil granule lumen] (Rattus norvegicus)

FTL [azurophil granule lumen] (Sus scrofa)

Fer2LCH [azurophil granule lumen] (Drosophila melanogaster)

Fer3HCH [azurophil granule lumen] (Drosophila melanogaster)

Homologues of FTL [azurophil granule lumen] (Caenorhabditis elegans)

Homologues of FTL [azurophil granule lumen] (Danio rerio)

Homologues of FTL [azurophil granule lumen] (Drosophila melanogaster)

Homologues of FTL [azurophil granule lumen] (Rattus norvegicus)

fthl27 [azurophil granule lumen] (Danio rerio)

Fer1HCH [azurophil granule lumen] (Drosophila melanogaster)

MGC75752 [azurophil granule lumen] (Xenopus tropicalis)

fthl28 [azurophil granule lumen] (Danio rerio)

fthl31 [azurophil granule lumen] (Danio rerio)

Ftl1l2 [azurophil granule lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_000137.2

OpenTargets

ENSG00000087086

HPA

ENSG00000087086-FTL

GeneCards

P02792

Ensembl

ENSP00000366525, ENSG00000087086, ENST00000331825

PRO

P02792

Pharos - Targets

P02792

Orphanet

16080

HMDB Protein

HMDBP02077

PDB

6TSF, 3KXU, 6TS1, 5LG8, 2FG4, 6TSJ, 2FG8, 4V6B, 6TR9, 6TSA, 6WX6, 6TS0, 2FFX

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.782	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	20
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.508	3

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