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PSEN1(1-298) [azurophil granule membrane]
Stable Identifier
R-HSA-6799209
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule membrane
Synonyms
Presenilin-1 N-term fragment, presenilin-1 NTF subunit
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule membrane proteins (Homo sapiens)
Azurophil granule membrane proteins [azurophil granule membrane] (Homo sapiens)
PSEN1(1-298) [azurophil granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49768 PSEN1
Gene Names
PSEN1, AD3, PS1, PSNL1
Chain
chain:1-298, chain:299-467, chain:346-467
Reference Genes
BioGPS Gene:5663 PSEN1
COSMIC (genes):PSEN1 PSEN1
CTD Gene:5663 PSEN1
dbSNP Gene:5663 PSEN1
ENSEMBL:ENSG00000080815 PSEN1
ENSEMBL_homo_sapiens_GENE:ENSG00000080815.20 PSEN1
HGNC:9508 PSEN1
KEGG Gene (Homo sapiens):5663 PSEN1
Monarch:5663 PSEN1
NCBI Gene:5663 PSEN1
OMIM:104311 PSEN1
UCSC:P49768 PSEN1
Reference Transcript
RefSeq:NM_000021.3 PSEN1
RefSeq:XM_005267866.1 PSEN1
RefSeq:NM_007318.2 PSEN1
RefSeq:XM_011536973.1 PSEN1
RefSeq:XM_011536971.2 PSEN1
RefSeq:XM_011536974.1 PSEN1
RefSeq:XM_005267864.2 PSEN1
RefSeq:XM_011536972.2 PSEN1
Other Identifiers
11718678_a_at
11718679_a_at
11749842_a_at
11756571_a_at
16786167
203460_PM_s_at
203460_s_at
207782_PM_s_at
207782_s_at
226577_PM_at
226577_at
238816_PM_at
238816_at
3543482
3543483
3543484
3543485
3543486
3543491
3543492
3543493
3543494
3543495
3543497
3543498
3543499
3543500
3543502
3543503
3543504
3543507
3543509
3543512
3543514
3543515
3543517
3543518
3543519
3543520
3543521
3543522
3543523
35658_at
54683_at
5663
641_at
642_s_at
77381_at
7975545
A_14_P113909
A_14_P134110
A_23_P106174
A_23_P205686
A_23_P340728
GE57790
GE84707
GO:0000045
GO:0000122
GO:0000139
GO:0000776
GO:0001568
GO:0001708
GO:0001756
GO:0001764
GO:0001921
GO:0001933
GO:0001934
GO:0001947
GO:0002038
GO:0002244
GO:0002265
GO:0002286
GO:0002376
GO:0002573
GO:0003407
GO:0003824
GO:0004175
GO:0004190
GO:0005215
GO:0005262
GO:0005515
GO:0005634
GO:0005635
GO:0005640
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005743
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005790
GO:0005791
GO:0005794
GO:0005813
GO:0005815
GO:0005856
GO:0005886
GO:0005929
GO:0005938
GO:0005975
GO:0006091
GO:0006351
GO:0006355
GO:0006486
GO:0006508
GO:0006509
GO:0006816
GO:0006839
GO:0006874
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0006954
GO:0006974
GO:0006979
GO:0007155
GO:0007219
GO:0007220
GO:0007420
GO:0007507
GO:0007611
GO:0007613
GO:0008013
GO:0008021
GO:0008233
GO:0009791
GO:0009986
GO:0010008
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0010975
GO:0012501
GO:0015031
GO:0015871
GO:0016020
GO:0016080
GO:0016192
GO:0016235
GO:0016324
GO:0016485
GO:0016787
GO:0019538
GO:0021549
GO:0021795
GO:0021870
GO:0021904
GO:0021987
GO:0022008
GO:0023052
GO:0030018
GO:0030054
GO:0030154
GO:0030163
GO:0030165
GO:0030182
GO:0030326
GO:0030424
GO:0030425
GO:0030426
GO:0030900
GO:0031410
GO:0031594
GO:0031901
GO:0031965
GO:0032092
GO:0032436
GO:0032469
GO:0032760
GO:0032991
GO:0034205
GO:0034330
GO:0035253
GO:0035282
GO:0035556
GO:0035577
GO:0036211
GO:0040011
GO:0042307
GO:0042325
GO:0042383
GO:0042500
GO:0042734
GO:0042982
GO:0042987
GO:0042995
GO:0043005
GO:0043011
GO:0043025
GO:0043065
GO:0043066
GO:0043085
GO:0043198
GO:0043226
GO:0043227
GO:0043524
GO:0043589
GO:0045121
GO:0045202
GO:0045296
GO:0045821
GO:0045893
GO:0048143
GO:0048167
GO:0048471
GO:0048538
GO:0048666
GO:0048705
GO:0048854
GO:0048856
GO:0048870
GO:0050435
GO:0050673
GO:0050771
GO:0050808
GO:0050820
GO:0050852
GO:0050877
GO:0051117
GO:0051208
GO:0051402
GO:0051563
GO:0051604
GO:0051966
GO:0055065
GO:0055085
GO:0055086
GO:0060075
GO:0060828
GO:0060999
GO:0070050
GO:0070588
GO:0070765
GO:0070851
GO:0097060
GO:0097190
GO:0098609
GO:0098693
GO:0098712
GO:0098794
GO:0098978
GO:0099175
GO:0140096
GO:0140249
GO:1901135
GO:1904646
GO:1904797
GO:1905908
GO:1990535
GO:2000059
GO:2001234
HMNXSV003003156
HMNXSV003031997
Hs.128490.0.S1_3p_at
Hs.16648.0.A1_3p_at
ILMN_1744267
ILMN_1796669
ILMN_1808548
ILMN_1809193
L76517_at
L76528_s_at
TC14000439.hg
TC14001762.hg
U40380_at
g7549812_3p_a_at
g7549814_3p_a_at
Participates
as a member of
Azurophil granule membrane proteins [azurophil granule membrane] (Homo sapiens)
Other forms of this molecule
PSEN1(1-467) [plasma membrane]
PSEN1(299-467) [azurophil granule membrane]
PSEN1(1-467) [azurophil granule membrane]
PSEN1(1-298) [plasma membrane]
PSEN1(299-467) [plasma membrane]
Inferred To
PSEN1 [azurophil granule membrane]
(Bos taurus)
PSEN1 [azurophil granule membrane]
(Canis familiaris)
PSEN1 [azurophil granule membrane]
(Gallus gallus)
PSEN1 [azurophil granule membrane]
(Sus scrofa)
psen1 [azurophil granule membrane]
(Danio rerio)
psen1 [azurophil granule membrane]
(Xenopus tropicalis)
psenA [azurophil granule membrane]
(Dictyostelium discoideum)
Homologues of PSEN1(1-298) [azurophil granule membrane]
(Dictyostelium discoideum)
psenB [azurophil granule membrane]
(Dictyostelium discoideum)
Psen1 [azurophil granule membrane]
(Mus musculus)
Psen1 [azurophil granule membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_005267921.1
,
NP_000012.1
,
NP_015557.2
,
XP_011535273.1
,
XP_005267923.1
,
XP_011535274.1
,
XP_011535275.1
,
XP_011535276.1
Guide to Pharmacology - Targets
2402
OpenTargets
ENSG00000080815
ZINC - Substances
PSN1_HUMAN
ZINC target
P49768
PRO
P49768
PDB
6LR4
,
7D8X
,
8K8E
,
5FN3
,
5FN4
,
8OQY
,
4UIS
,
8OQZ
,
2KR6
,
5A63
,
7C9I
,
6LQG
,
5FN5
,
6IDF
,
5FN2
,
8IM7
,
7Y5T
,
6IYC
GeneCards
P49768
HPA
ENSG00000080815-PSEN1
Ensembl
ENSP00000452242
,
ENST00000700306
,
ENSP00000451915
,
ENST00000556951
,
ENST00000700269
,
ENST00000394164
,
ENSP00000514904
,
ENSP00000514966
,
ENSP00000377719
,
ENSP00000326366
,
ENST00000700321
,
ENST00000700313
,
ENSP00000450845
,
ENSP00000514950
,
ENSP00000514968
,
ENSP00000450551
,
ENST00000324501
,
ENST00000394157
,
ENST00000700268
,
ENST00000700265
,
ENSP00000514905
,
ENSP00000514944
,
ENSP00000514940
,
ENST00000700378
,
ENST00000553855
,
ENST00000700469
,
ENSP00000514948
,
ENSP00000514970
,
ENSP00000514903
,
ENST00000700267
,
ENST00000700323
,
ENSP00000515002
,
ENST00000700322
,
ENST00000700317
,
ENSP00000377712
,
ENSG00000080815
,
ENST00000553599
,
ENST00000700436
,
ENST00000700273
,
ENSP00000514933
,
ENST00000557511
,
ENST00000357710
,
ENSP00000350342
,
ENST00000700375
,
ENSP00000514951
,
ENSP00000452477
,
ENST00000700324
,
ENSP00000451429
,
ENSP00000514901
,
ENST00000700389
,
ENSP00000514908
,
ENST00000555386
,
ENST00000554131
,
ENSP00000514987
,
ENSP00000514949
Pharos - Targets
P49768
ZINC - Predictions - Purchasable
PSN1_HUMAN
Orphanet
15160
HMDB Protein
HMDBP07957
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067-4 APP
2
APP (535-695) [cytosol]
(R-HSA-9839084)
APP [mitochondrial inner membrane]
(R-HSA-9839060)
0.702
4
UniProt:Q02410 APBA1
1
APBA1 [cytosol]
(R-HSA-5336459)
0.697
4
UniProt:P56817 BACE1
8
BACE1 [endoplasmic reticulum lumen]
(R-HSA-6783326)
7K-BACE1 [endoplasmic reticulum lumen]
(R-HSA-5693006)
BACE1(22-45) [Golgi-associated vesicle lumen]
(R-HSA-5693069)
7K-BACE1 [Golgi-associated vesicle lumen]
(R-HSA-5693095)
7K-BACE1(46-501) [Golgi-associated vesicle lumen]
(R-HSA-5693106)
BACE1(46-501) [Golgi-associated vesicle lumen]
(R-HSA-5693105)
BACE1(46-501) [plasma membrane]
(R-HSA-5692933)
BACE1 [endosome membrane]
(R-HSA-5692942)
0.639
6
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.632
6
UniProt:Q9NZC2 TREM2
1
TREM2 [plasma membrane]
(R-HSA-197664)
0.599
5
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.582
4
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.564
2
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.508
2
UniProt:O75369 FLNB
1
FLNB [cytosol]
(R-HSA-354163)
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
5
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.462
3
UniProt:Q15392 DHCR24
1
DHCR24 [endoplasmic reticulum membrane]
(R-HSA-196414)
0.462
3
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