Reactome | PSEN1(1-467) [azurophil granule membrane]

PSEN1(1-467) [azurophil granule membrane]

Stable Identifier

R-HSA-6799235

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule membrane

Synonyms

PSEN1, Presenilin-1 precursor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49768 PSEN1

Gene Names

PSEN1, AD3, PS1, PSNL1

Chain

chain:1-298, chain:299-467, chain:346-467

Reference Genes

BioGPS Gene:5663 PSEN1

COSMIC (genes):PSEN1 PSEN1

CTD Gene:5663 PSEN1

dbSNP Gene:5663 PSEN1

ENSEMBL:ENSG00000080815.19 PSEN1

HGNC:9508 PSEN1

KEGG Gene (Homo sapiens):5663 PSEN1

Monarch:5663 PSEN1

NCBI Gene:5663 PSEN1

OMIM:104311 PSEN1

UCSC:P49768 PSEN1

Reference Transcript

Other Identifiers

0002640500

0002640600

0007040537

11718678_a_at

11718679_a_at

11749842_a_at

11756571_a_at

16786167

203460_PM_s_at

203460_s_at

207782_PM_s_at

207782_s_at

226577_PM_at

226577_at

238816_PM_at

238816_at

3543482

3543483

3543484

3543485

3543486

3543492

3543493

3543494

3543495

3543497

3543498

3543499

3543500

3543502

3543503

3543504

3543507

3543509

3543512

3543514

3543515

3543517

3543518

3543519

3543520

3543521

3543522

3543523

35658_at

54683_at

5663

641_at

642_s_at

77381_at

7975545

A_14_P113909

A_14_P134110

A_23_P106174

A_23_P205686

A_23_P340728

GE57790

GE84707

GO:0000045

GO:0000122

GO:0000139

GO:0000776

GO:0001568

GO:0001708

GO:0001756

GO:0001764

GO:0001921

GO:0001933

GO:0001934

GO:0001947

GO:0002038

GO:0002244

GO:0002265

GO:0002286

GO:0002376

GO:0002573

GO:0003407

GO:0004175

GO:0004190

GO:0005215

GO:0005262

GO:0005515

GO:0005622

GO:0005634

GO:0005635

GO:0005640

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005783

GO:0005789

GO:0005790

GO:0005791

GO:0005794

GO:0005813

GO:0005815

GO:0005856

GO:0005886

GO:0005887

GO:0005929

GO:0005938

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0006469

GO:0006486

GO:0006508

GO:0006509

GO:0006816

GO:0006839

GO:0006874

GO:0006886

GO:0006913

GO:0006914

GO:0006915

GO:0006954

GO:0006974

GO:0006979

GO:0007155

GO:0007175

GO:0007176

GO:0007219

GO:0007220

GO:0007420

GO:0007507

GO:0007611

GO:0007613

GO:0008013

GO:0008021

GO:0008233

GO:0009791

GO:0009986

GO:0010008

GO:0010467

GO:0010468

GO:0010628

GO:0010629

GO:0010975

GO:0012501

GO:0015031

GO:0015871

GO:0016020

GO:0016021

GO:0016080

GO:0016192

GO:0016235

GO:0016324

GO:0016485

GO:0016787

GO:0019538

GO:0021549

GO:0021795

GO:0021870

GO:0021904

GO:0021987

GO:0022008

GO:0023052

GO:0030018

GO:0030054

GO:0030154

GO:0030163

GO:0030165

GO:0030182

GO:0030326

GO:0030424

GO:0030425

GO:0030426

GO:0030900

GO:0031410

GO:0031594

GO:0031901

GO:0031965

GO:0032092

GO:0032436

GO:0032469

GO:0032760

GO:0032991

GO:0034205

GO:0034330

GO:0035253

GO:0035282

GO:0035556

GO:0035577

GO:0036211

GO:0040011

GO:0042307

GO:0042325

GO:0042327

GO:0042383

GO:0042500

GO:0042982

GO:0042987

GO:0042995

GO:0043005

GO:0043011

GO:0043025

GO:0043065

GO:0043066

GO:0043085

GO:0043198

GO:0043226

GO:0043227

GO:0043393

GO:0043406

GO:0043524

GO:0043589

GO:0045121

GO:0045202

GO:0045296

GO:0045821

GO:0045860

GO:0045893

GO:0048143

GO:0048167

GO:0048471

GO:0048538

GO:0048666

GO:0048705

GO:0048854

GO:0048856

GO:0048870

GO:0050435

GO:0050673

GO:0050771

GO:0050808

GO:0050820

GO:0050852

GO:0050877

GO:0051117

GO:0051208

GO:0051402

GO:0051444

GO:0051563

GO:0051604

GO:0051966

GO:0055065

GO:0055085

GO:0055086

GO:0060075

GO:0060828

GO:0060999

GO:0070050

GO:0070161

GO:0070588

GO:0070765

GO:0070851

GO:0071944

GO:0097060

GO:0097190

GO:0098609

GO:0098712

GO:0099056

GO:0140096

GO:1901135

GO:1904646

GO:1904797

GO:1905908

GO:1990535

GO:2000059

GO:2001234

HMNXSV003003156

HMNXSV003031997

Hs.128490.0.S1_3p_at

Hs.16648.0.A1_3p_at

ILMN_1744267

ILMN_1808548

ILMN_1809193

L76517_at

L76528_s_at

TC14000439.hg

TC14001762.hg

U40380_at

g7549812_3p_a_at

g7549814_3p_a_at

Participates

as a member of

Azurophil granule membrane proteins [azurophil granule membrane] (Homo sapiens)

Other forms of this molecule

PSEN1(1-467) [plasma membrane]

PSEN1(299-467) [azurophil granule membrane]

PSEN1(1-298) [azurophil granule membrane]

PSEN1(1-298) [plasma membrane]

PSEN1(299-467) [plasma membrane]

Inferred To

Psn [azurophil granule membrane] (Drosophila melanogaster)

hop-1 [azurophil granule membrane] (Caenorhabditis elegans)

PSEN1(1-467) [azurophil granule membrane] (Canis familiaris)

Homologues of PSEN1(1-467) [azurophil granule membrane] (Caenorhabditis elegans)

Homologues of PSEN1(1-467) [azurophil granule membrane] (Dictyostelium discoideum)

PSEN1 [azurophil granule membrane] (Bos taurus)

PSEN1 [azurophil granule membrane] (Gallus gallus)

PSEN1 [azurophil granule membrane] (Sus scrofa)

psen1 [azurophil granule membrane] (Danio rerio)

psen1 [azurophil granule membrane] (Xenopus tropicalis)

sel-12 [azurophil granule membrane] (Caenorhabditis elegans)

psenA [azurophil granule membrane] (Dictyostelium discoideum)

psenB [azurophil granule membrane] (Dictyostelium discoideum)

Psen1 [azurophil granule membrane] (Mus musculus)

Psen1 [azurophil granule membrane] (Rattus norvegicus)

spe-4 [azurophil granule membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011535273.1, XP_011535275.1, NP_000012.1, XP_005267923.1, NP_015557.2, XP_005267921.1, XP_011535276.1, XP_011535274.1

Guide to Pharmacology - Targets

2402

OpenTargets

ENSG00000080815

ZINC - Substances

PSN1_HUMAN

ZINC target

P49768

PRO

P49768

PDB

5FN2, 6IDF, 5FN4, 5FN5, 6LR4, 6LQG, 5FN3, 5A63, 2KR6, 4UIS, 6IYC, 7D8X, 7C9I

GeneCards

P49768

HPA

ENSG00000080815-PSEN1

Ensembl

ENSP00000451429, ENSG00000080815, ENST00000394164, ENSP00000350342, ENST00000394157, ENSP00000377719, ENSP00000377712, ENST00000324501, ENST00000555386, ENST00000557511, ENST00000553855, ENST00000357710, ENSP00000450845, ENSP00000452242, ENSP00000326366

Pharos - Targets

P49768

Orphanet

15160

ZINC - Predictions - Purchasable

PSN1_HUMAN

HMDB Protein

HMDBP07957

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.697	4
UniProt:P56817 BACE1	8	BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.639	6
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.632	6
UniProt:Q9NZC2 TREM2	1	TREM2 [plasma membrane] (R-HSA-197664)	0.599	5
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.582	4
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.564	2
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.508	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.508	2
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.462	3
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.462	3