Reactome | TOM1 [azurophil granule membrane]

TOM1 [azurophil granule membrane]

Stable Identifier

R-HSA-6799348

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule membrane

Synonyms

Target of Myb protein 1, TOM1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60784 TOM1

Gene Names

TOM1

Chain

chain:1-492

Reference Genes

BioGPS Gene:10043 TOM1

COSMIC (genes):TOM1 TOM1

CTD Gene:10043 TOM1

dbSNP Gene:10043 TOM1

ENSEMBL:ENSG00000100284 TOM1

HGNC:11982 TOM1

KEGG:hsa:10043 TOM1

Monarch:10043 TOM1

NCBI Gene:10043 TOM1

OMIM:604700 TOM1

UCSC:O60784 TOM1

Reference Transcript

Participates

as a member of

Azurophil granule membrane proteins [azurophil granule membrane] (Homo sapiens)

Other forms of this molecule

TOM1 [plasma membrane]

TOM1 [specific granule membrane]

Inferred To

tom1 [azurophil granule membrane] (Xenopus tropicalis)

Tom1 [azurophil granule membrane] (Mus musculus)

Tom1 [azurophil granule membrane] (Rattus norvegicus)

DmTOM1 [azurophil granule membrane] (Drosophila melanogaster)

TOM1 [azurophil granule membrane] (Bos taurus)

TOM1 [azurophil granule membrane] (Caenorhabditis elegans)

TOM1 [azurophil granule membrane] (Canis familiaris)

TOM1 [azurophil granule membrane] (Gallus gallus)

TOM1 [azurophil granule membrane] (Sus scrofa)

Cross References

ENSEMBL

ENST00000447733, ENST00000411850, ENST00000449058, ENSP00000394924, ENST00000425375, ENSP00000394466, ENSP00000413697, ENSG00000100284, ENSP00000398876

OpenTargets

ENSG00000100284

GeneCards

TOM1

HPA

ENSG00000100284-TOM1

PRO

O60784

Pharos - Targets

O60784

Orphanet

TOM1

PDB

1WRD, 1ELK, 6J56, 2N2N, 2N9D

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.851	8
UniProt:P0CG53	20	UBB [endocytic vesicle membrane] (R-BTA-939253) UBB [endocytic vesicle membrane] (R-BTA-939231) UBB [endocytic vesicle membrane] (R-BTA-939171) UBB [mitochondrial outer membrane] (R-BTA-6783023) UBB [mitochondrial outer membrane] (R-BTA-6783008) UBB [mitochondrial outer membrane] (R-BTA-6783046) UBB [mitochondrial outer membrane] (R-BTA-6783002) UBB [mitochondrial outer membrane] (R-BTA-6783148) UBB [mitochondrial outer membrane] (R-BTA-6783012) UBB [mitochondrial outer membrane] (R-BTA-6783162) UBB [mitochondrial outer membrane] (R-BTA-6783014) UBB [mitochondrial outer membrane] (R-BTA-6783015) UBB [mitochondrial outer membrane] (R-BTA-6783025) UBB [mitochondrial outer membrane] (R-BTA-6782998) UBB [mitochondrial outer membrane] (R-BTA-6783109) UBB [mitochondrial outer membrane] (R-BTA-6783131) UBB [mitochondrial outer membrane] (R-BTA-6783100) UBB [mitochondrial outer membrane] (R-BTA-6783165) UBB [mitochondrial outer membrane] (R-BTA-6783160) UBB [mitochondrial outer membrane] (R-BTA-6783070)	0.743	6
UniProt:Q7Z3T8 ZFYVE16	1	ZFYVE16 [early endosome membrane] (R-HSA-201645)	0.736	6
UniProt:Q9UM54 MYO6	3	MYO6 [plasma membrane] (R-HSA-3006691) MYO6 [lysosomal membrane] (R-HSA-3006694) MYO6 [cytosol] (R-HSA-3006692)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3