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DNASE1L1 [specific granule lumen]
Stable Identifier
R-HSA-6799554
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
specific granule lumen
Synonyms
Deoxyribonuclease-1-like 1 ecNumber3.1.21.-/ecNumber, DNSL1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
Specific granule lumen proteins [specific granule lumen] (Homo sapiens)
DNASE1L1 [specific granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49184 DNASE1L1
Gene Names
DNASE1L1, DNAS1L1, DNL1L
Chain
signal peptide:1-18, chain:19-302
Reference Genes
BioGPS Gene:1774 DNASE1L1
COSMIC (genes):DNASE1L1 DNASE1L1
CTD Gene:1774 DNASE1L1
dbSNP Gene:1774 DNASE1L1
ENSEMBL:ENSG00000013563 DNASE1L1
HGNC:2957 DNASE1L1
KEGG:hsa:1774 DNASE1L1
Monarch:1774 DNASE1L1
NCBI Gene:1774 DNASE1L1
OMIM:300081 DNASE1L1
UCSC:P49184 DNASE1L1
Reference Transcript
RefSeq:XM_005277829.4 DNASE1L1
RefSeq:NM_001303620.1 DNASE1L1
RefSeq:NM_006730.3 DNASE1L1
RefSeq:XM_011531122.2 DNASE1L1
RefSeq:NM_001009934.2 DNASE1L1
RefSeq:XM_017029332.1 DNASE1L1
RefSeq:NM_001009933.2 DNASE1L1
RefSeq:NM_001009932.2 DNASE1L1
Other Identifiers
11741203_a_at
11755208_a_at
17115571
1774
203912_PM_s_at
203912_s_at
2886166
37213_at
37214_g_at
3821801
4027297
4027298
4027299
4027301
4027303
4027304
4027305
4027306
4027307
4027308
4027309
4027311
4027312
4027313
4027314
4027315
4027317
4027318
4027320
4027321
4027323
78701_at
8176076
A_23_P85164
A_32_P161166
GE60127
GO:0003677
GO:0003824
GO:0004518
GO:0004519
GO:0004530
GO:0004536
GO:0005515
GO:0005576
GO:0005634
GO:0005783
GO:0006259
GO:0006308
GO:0016787
GO:0035580
GO:0043226
GO:0140097
HMNXSV003000427
HMNXSV003011836
HMNXSV003048908
ILMN_1681695
ILMN_1801230
ILMN_2256081
ILMN_2380967
L44140_cds4_s_at
PH_hs_0004445
TC0X001532.hg
X90392_at
g5803006_3p_a_at
p33947
Participates
as a member of
Specific granule lumen proteins [specific granule lumen] (Homo sapiens)
Other forms of this molecule
DNASE1L1 [extracellular region]
Inferred To
LOC116406574 [specific granule lumen]
(Xenopus tropicalis)
DNASE1L1 [specific granule lumen]
(Bos taurus)
DNASE1L1 [specific granule lumen]
(Canis familiaris)
DNASE1L1 [specific granule lumen]
(Sus scrofa)
Dnase1l1 [specific granule lumen]
(Mus musculus)
Dnase1l1 [specific granule lumen]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000309168
,
ENSP00000358822
,
ENSP00000377255
,
ENSP00000358823
,
ENST00000014935
,
ENST00000369807
,
ENSP00000358824
,
ENST00000369808
,
ENST00000369809
,
ENST00000309585
,
ENST00000393638
,
ENSP00000014935
OpenTargets
ENSG00000013563
HPA
ENSG00000013563-DNASE1L1
PRO
P49184
Pharos - Targets
P49184
GlyGen
P49184
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.564
3
UniProt:P12830 CDH1
8
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
DLST [mitochondrial matrix]
(R-HSA-6792574)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.556
3
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
UniProt:Q15078 CDK5R1
4
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.556
3
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