GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

Stable Identifier
R-HSA-6799604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catalyse the reversible deamination and with an aldo/keto isomerisation of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate (Fru(6)P) and ammonia (NH3). GNDPA1 and 2 function as homohexamers in the cytosol. This reaction could provide a source of energy from catabolic pathways of hexosamines found in glycoproteins and glycolipids (Wolosker et al. 1998, Zhang et al. 2003, Arreola et al. 2003).
Literature References
PubMed ID Title Journal Year
12616532 Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin

Chen, G, Wan, T, Li, N, Zou, D, Cao, X, Zhang, W, Zhang, J

J. Cell. Biochem. 2003
9438414 Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity

Schnaar, RL, Wolosker, H, Kline, D, Cameron, AM, Snyder, SH, Blackshaw, S, Bian, Y, Fralich, TJ

FASEB J. 1998
12965206 Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study

Horjales, E, Arreola, R, Morante, ML, Valderrama, B

FEBS Lett. 2003
Participants
Participates
Event Information
Catalyst Activity

glucosamine-6-phosphate deaminase activity of GNPDA1,2 hexamers [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!