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PTPRB [specific granule membrane]
Stable Identifier
R-HSA-6799638
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
specific granule membrane
Synonyms
RPTPbeta, Receptor-type tyrosine-protein phosphatase beta, PTPRB_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [specific granule membrane] (Homo sapiens)
PTPRB [specific granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23467 PTPRB
Gene Names
PTPRB, PTPB
Chain
signal peptide:1-22, chain:23-1997
Reference Genes
BioGPS Gene:5787 PTPRB
COSMIC (genes):PTPRB PTPRB
CTD Gene:5787 PTPRB
dbSNP Gene:5787 PTPRB
ENSEMBL:ENSG00000127329 PTPRB
ENSEMBL_homo_sapiens_GENE:ENSG00000127329.16 PTPRB
HGNC:9665 PTPRB
KEGG Gene (Homo sapiens):5787 PTPRB
Monarch:5787 PTPRB
NCBI Gene:5787 PTPRB
OMIM:176882 PTPRB
UCSC:P23467 PTPRB
Reference Transcript
RefSeq:NM_001109754.3 PTPRB
RefSeq:NM_001330204.1 PTPRB
RefSeq:NM_002837.5 PTPRB
RefSeq:NM_001206971.2 PTPRB
RefSeq:NM_001206972.2 PTPRB
Other Identifiers
11733229_a_at
11733230_a_at
11733231_a_at
11752192_x_at
16767422
205846_PM_at
205846_at
217177_PM_s_at
217177_s_at
230250_PM_at
230250_at
33066_at
3461796
3461797
3461798
3461799
3461800
3461801
3461802
3461803
3461804
3461805
3461809
3461812
3461813
3461815
3461816
3461817
3461820
3461823
3461824
3461826
3461827
3461828
3461831
3461832
3461833
3461834
3461838
3461839
3461840
3461841
3461842
3461843
3461844
3461845
3461848
3461850
3461851
3461852
3461855
3461859
3461862
3461866
3461868
3461869
3461874
3461875
3461876
3461877
3461878
3461879
37777_at
407_at
5787
7964872
A_23_P53390
A_24_P661612
A_32_P94851
GE56336
GE59789
GE874747
GO:0001525
GO:0003824
GO:0004721
GO:0004725
GO:0005001
GO:0005515
GO:0005886
GO:0006470
GO:0006796
GO:0008347
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0030154
GO:0031410
GO:0035579
GO:0036211
GO:0043226
GO:0043235
GO:0045296
GO:0048856
GO:0048870
GO:0060089
GO:0070821
GO:0140096
HMNXSV003020137
HMNXSV003034151
Hs.123641.1.A1_3p_at
Hs.149770.0.S1_3p_a_at
ILMN_1672102
ILMN_1821052
PH_hs_0025326
TC12001718.hg
X54131_at
g4506304_3p_at
Participates
as a member of
Specific granule membrane proteins [specific granule membrane] (Homo sapiens)
Other forms of this molecule
PTPRB [plasma membrane]
PTPRB [tertiary granule membrane]
Inferred To
PTPRB [specific granule membrane]
(Bos taurus)
PTPRB [specific granule membrane]
(Canis familiaris)
PTPRB [specific granule membrane]
(Gallus gallus)
PTPRB [specific granule membrane]
(Mus musculus)
PTPRB [specific granule membrane]
(Sus scrofa)
Ptprb [specific granule membrane]
(Rattus norvegicus)
ptprb [specific granule membrane]
(Danio rerio)
Cross References
RefSeq
NP_002828.3
,
NP_001103224.1
,
NP_001193900.1
,
NP_001317133.1
,
NP_001193901.1
Guide to Pharmacology - Targets
1851
OpenTargets
ENSG00000127329
ZINC - Substances
PTPRB_HUMAN
ZINC target
P23467
PRO
P23467
PDB
2I5X
,
2I3R
,
2I4H
,
2I4E
,
2I3U
,
2H04
,
8JBY
,
2H02
,
2HC1
,
2I4G
,
8JBN
,
2AHS
,
2H03
,
2HC2
HPA
ENSG00000127329-PTPRB
GeneCards
P23467
Ensembl
ENST00000550857
,
ENSP00000447302
,
ENSG00000127329
,
ENSP00000334928
,
ENSP00000438927
,
ENSP00000261266
,
ENST00000334414
,
ENST00000261266
,
ENST00000538708
Pharos - Targets
P23467
ZINC - Predictions - Purchasable
PTPRB_HUMAN
HMDB Protein
HMDBP08940
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.692
3
UniProt:P10912 GHR
7
p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]
(R-HSA-1169226)
GHR(257-638) [plasma membrane]
(R-HSA-1168803)
p-5Y-GHR(19-638) [plasma membrane]
(R-HSA-1168904)
GHR(19-638) [endosome lumen]
(R-HSA-1169263)
GHR(19-256) [extracellular region]
(R-HSA-1168821)
GHR(19-638) [plasma membrane]
(R-HSA-982779)
GHR activated [plasma membrane]
(R-HSA-1168385)
0.683
3
UniProt:P27361 MAPK3
6
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [nucleoplasm]
(R-HSA-73724)
MAPK3 [cytosol]
(R-HSA-59284)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
0.623
2
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