Reactome | TMC6 [specific granule membrane]

TMC6 [specific granule membrane]

Stable Identifier

R-HSA-6799712

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

Transmembrane channel-like protein 6, TMC6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q7Z403 TMC6

Gene Names

TMC6, EVER1, EVIN1

Chain

chain:1-805

Reference Genes

BioGPS Gene:11322 TMC6

COSMIC (genes):TMC6 TMC6

CTD Gene:11322 TMC6

dbSNP Gene:11322 TMC6

ENSEMBL:ENSG00000141524 TMC6

ENSEMBL_homo_sapiens_GENE:ENSG00000141524.19 TMC6

HGNC:18021 TMC6

KEGG Gene (Homo sapiens):11322 TMC6

Monarch:11322 TMC6

NCBI Gene:11322 TMC6

OMIM:605828 TMC6

UCSC:Q7Z403 TMC6

Reference Transcript

Other Identifiers

11322

11719431_a_at

11752637_a_at

11752638_x_at

11761269_x_at

16849349

16849355

204328_PM_at

204328_at

214958_3p_s_at

214958_PM_s_at

214958_s_at

228591_PM_at

228591_at

230526_PM_at

230526_at

239062_PM_at

239062_at

2409184

242364_PM_x_at

242364_x_at

32116_at

3772086

3772088

3772089

3772091

3772092

3772093

3772094

3772095

3772096

3772097

3772098

3772099

3772100

3772101

3772105

3772106

3772107

3772108

3772110

3772111

3772114

3772117

3772118

3772119

3772121

3772124

3772125

3772126

3772127

3772129

3772130

3772131

3772133

3772134

3772135

3772136

3772137

3772138

3772141

3772142

3772143

3772145

54483_at

57763_at

8018823

89316_at

91502_at

A_23_P101013

A_24_P857624

A_32_P19000

GE53101

GE86244

GO:0005215

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006811

GO:0008150

GO:0008381

GO:0016020

GO:0031410

GO:0031965

GO:0034220

GO:0035579

GO:0043226

GO:0055085

GO:0070062

GO:0070821

HMNXSV003017549

HMNXSV003026577

Hs.182562.0.A1_3p_at

Hs.182562.1.A1_3p_a_at

Hs.62529.0.A1_3p_at

Hs.80618.1.A1_3p_at

ILMN_1794677

PH_hs_0027086

TC17001912.hg

TC17001913.hg

TC17002799.hg

g7305226_3p_at

p29179

p7064

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

TMC6 [tertiary granule membrane]

TMC6 [plasma membrane]

Inferred To

TMC6 [specific granule membrane] (Bos taurus)

TMC6 [specific granule membrane] (Canis familiaris)

TMC6 [specific granule membrane] (Gallus gallus)

TMC6 [specific granule membrane] (Sus scrofa)

Tmc6 [specific granule membrane] (Mus musculus)

Tmc6 [specific granule membrane] (Rattus norvegicus)

tmc6 [specific granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_005257052.1, NP_001120670.1, XP_011522557.1, NP_001308114.1, NP_009198.4

OpenTargets

ENSG00000141524

HPA

ENSG00000141524-TMC6

GeneCards

Q7Z403

Ensembl

ENST00000698550, ENST00000590602, ENSP00000466885, ENSP00000313408, ENSP00000513793, ENST00000592063, ENST00000589271, ENSG00000141524, ENST00000322914, ENST00000392467, ENSP00000306405, ENST00000306591, ENSP00000465261, ENSP00000376260, ENSP00000468255

PRO

Q7Z403

Pharos - Targets

Q7Z403

Orphanet

17300

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3