Reactome | MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG

MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG

Stable Identifier

R-HSA-6800334

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Triacylglycerol (TG) is a non-polar acyl triester of glycerol and fatty acids. TG serves primarily as a reservoir of fatty acids for energy production. TG synthesis in all organisms occurs via the conserved canonical pathway known as the Kennedy or sn-glycerol-3-phosphate (G3P) pathway. Diacylglycerol (DAG), an intermediate in the Kennedy pathway, can also enter this pathway via an alternative route known as the remodeling pathway which dominates in the small intestine where most dietary fat is absorbed. In this pathway, monoacylglycerol is acylated, mediated by monoacylglycerol acyltransferases 1, 2 and 3 (MOGAT1, 2 and 3) to form DAG (Winter et al. 2003, Lockwood et al. 2003, Cheng et al. 2003, Yu et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
12824082	Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity Lockwood, JF, Shi, Y, Cao, J, Burn, P	Am. J. Physiol. Endocrinol. Metab.	2003
14970677	Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals Bininda-Emonds, OR, Fries, R, Winter, A, van Eckeveld, M, Habermann, FA	Cytogenet. Genome Res.	2003
25838202	Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor Î³ in human hepatocytes and increases lipid accumulation Choi, Y, Seok, JW, Yu, JH, Kim, HJ, Lee, YJ, Choi, H, Kim, JW	Biochem. Biophys. Res. Commun.	2015
12618427	Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption Billheimer, JT, Taub, R, Cheng, D, Nelson, TC, Wardwell-Swanson, J, Ramaker, M, Meegalla, R, Walker, SG, Feder, JN, Chen, J	J. Biol. Chem.	2003