Reactome | PSMD6 [ficolin-1-rich granule lumen]

PSMD6 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6800440

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit S10, p42A, Proteasome regulatory particle subunit p44S10

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15008 PSMD6

Gene Names

PSMD6, KIAA0107, PFAAP4

Chain

initiator methionine:, chain:2-389

Reference Genes

BioGPS Gene:9861 PSMD6

COSMIC (genes):PSMD6 PSMD6

CTD Gene:9861 PSMD6

dbSNP Gene:9861 PSMD6

ENSEMBL:ENSG00000163636 PSMD6

ENSEMBL_homo_sapiens_GENE:ENSG00000163636.11 PSMD6

HGNC:9564 PSMD6

KEGG Gene (Homo sapiens):9861 PSMD6

Monarch:9861 PSMD6

NCBI Gene:9861 PSMD6

OMIM:617857 PSMD6

UCSC:Q15008 PSMD6

Reference Transcript

Other Identifiers

11731415_a_at

11746510_x_at

16955771

202753_3p_at

202753_PM_at

202753_at

2679865

2679866

2679867

2679869

2679872

2679876

2679877

2679878

2679879

2679881

2679884

2679885

2679886

2679887

34680_s_at

8088535

9861

A_23_P109928

D14663_at

GE54973

GO:0000502

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0022624

GO:0030163

GO:0031410

GO:0034774

GO:0043161

GO:0043226

GO:1904813

HMNXSV003039793

ILMN_1779633

ILMN_2155998

PH_hs_0016942

TC03001522.hg

g7661913_3p_at

g7661913_3p_s_at

Participates

as a member of

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD6 [secretory granule lumen]

PSMD6 [extracellular region]

PSMD6 [nucleoplasm]

PSMD6 [cytosol]

Inferred To

psmD6 [ficolin-1-rich granule lumen] (Dictyostelium discoideum)

rpn7 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

Psmd6 [ficolin-1-rich granule lumen] (Mus musculus)

Psmd6 [ficolin-1-rich granule lumen] (Rattus norvegicus)

rpn-7 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

RPN7 [ficolin-1-rich granule lumen] (Saccharomyces cerevisiae)

Rpn7 [ficolin-1-rich granule lumen] (Drosophila melanogaster)

psmd6 [ficolin-1-rich granule lumen] (Danio rerio)

psmd6 [ficolin-1-rich granule lumen] (Xenopus tropicalis)

PSMD6 [ficolin-1-rich granule lumen] (Bos taurus)

PSMD6 [ficolin-1-rich granule lumen] (Canis familiaris)

PSMD6 [ficolin-1-rich granule lumen] (Gallus gallus)

PSMD6 [ficolin-1-rich granule lumen] (Plasmodium falciparum)

PSMD6 [ficolin-1-rich granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_001258710.1, NP_055629.1, NP_001258709.1, NP_001258708.1

OpenTargets

ENSG00000163636

GeneCards

Q15008

HPA

ENSG00000163636-PSMD6

Ensembl

ENSP00000418695, ENST00000482510, ENSP00000295901, ENSG00000163636, ENSP00000377952, ENST00000394431, ENSP00000419227, ENST00000492933, ENST00000295901

PRO

Q15008

Pharos - Targets

Q15008

PDB

5T0J, 5VFR, 6WJN, 7QXN, 5T0I, 5VFP, 7QXX, 6MSB, 8CVT, 7QY7, 5VFT, 7W3I, 7W38, 5L4K, 7QXU, 5GJQ, 7QXW, 6MSG, 5VHH, 5VFU, 7W3G, 7W3H, 6MSD, 7W37, 7W3K, 5GJR, 7W3M, 7W3C, 5T0G, 7W3F, 5VGZ, 7W3J, 5VFQ, 7QYA, 7W3A, 5T0H, 7QYB, 5VHF, 5VFS, 7W39, 5T0C, 5LN3, 6MSH, 5VHI, 5M32, 7QXP, 6MSK, 7W3B, 5VHS, 6MSJ, 6WJD

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.802	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	6
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.758	5
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.744	6
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.744	5
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.744	6
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.744	4
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.744	7
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.744	4
UniProt:Q99436 PSMB7	7	PSMB7(1-43) [cytosol] (R-HSA-9908129) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.669	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.669	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.669	4
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.669	5
UniProt:Q9UNM6 PSMD13	5	PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.669	6
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.667	3
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.667	4
UniProt:Q16186 ADRM1	2	ADRM1 [nucleoplasm] (R-HSA-9918361) ADRM1 [cytosol] (R-HSA-5665939)	0.643	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.589	2
UniProt:P28074 PSMB5	4	PSMB5(1-59) [cytosol] (R-HSA-9908134) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5 [nucleoplasm] (R-HSA-174344) PSMB5 [cytosol] (R-HSA-68753)	0.564	2
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.564	2
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.564	3
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.564	2
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.564	2
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.564	2
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.564	3
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.564	3
UniProt:Q9UMX0-2 UBQLN1			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.556	5
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:P20133	2	RABGGTB [cytosol] (R-SCE-8870419) RABGGTB [plasma membrane] (R-SCE-6801098)	0.556	3
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.527	3
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.527	3
UniProt:P28065 PSMB9	3	PSMB9(1-20) [cytosol] (R-HSA-9908132) PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136)	0.527	4
UniProt:Q96G75 RMND5B	1	RMND5B [cytosol] (R-HSA-9861550)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

Cite Us!