Reactome | PERP [plasma membrane]

PERP [plasma membrane]

Stable Identifier

R-HSA-6800837

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p53 apoptosis effector related to PMP-22

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 or TP63 stimulates PERP gene expression (Homo sapiens)
        
        PERP [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96FX8 PERP

Gene Names

PERP, KCP1, KRTCAP1, PIGPC1, THW

Chain

chain:1-193

Reference Genes

BioGPS Gene:64065 PERP

COSMIC (genes):PERP PERP

CTD Gene:64065 PERP

dbSNP Gene:64065 PERP

ENSEMBL:ENSG00000112378.12 PERP

HGNC:17637 PERP

KEGG Gene (Homo sapiens):64065 PERP

Monarch:64065 PERP

NCBI Gene:64065 PERP

OMIM:609301 PERP

UCSC:Q96FX8 PERP

Reference Transcript

RefSeq:NM_022121.4 PERP

Other Identifiers

0003780110

11726974_a_at

11726975_x_at

11726976_at

17024187

217744_PM_s_at

217744_s_at

222392_PM_x_at

222392_x_at

236009_PM_at

236009_at

2976365

2976366

2976367

2976368

2976369

2976370

2976371

2976378

2976389

2976390

2976391

2976392

2976393

45333_at

47929_at

57141_f_at

57143_r_at

64065

8129880

86566_r_at

A_23_P214950

GE752888

GE82658

GO:0002934

GO:0005515

GO:0005622

GO:0005737

GO:0005739

GO:0005794

GO:0005886

GO:0005887

GO:0005911

GO:0006915

GO:0007155

GO:0007219

GO:0012501

GO:0016020

GO:0016021

GO:0023052

GO:0030057

GO:0034113

GO:0034330

GO:0043226

GO:0045862

GO:0048856

GO:0051604

GO:0070161

GO:0072332

GO:0097186

GO:0097202

GO:0098609

HMNXSV003045055

Hs.165240.0.A1_3p_at

Hs.303125.0.S2_3p_at

Hs.303125.0.S2_3p_x_at

ILMN_1726161

ILMN_1775829

PH_hs_0011810

PH_hs_0027878

PH_hs_0031849

TC06002157.hg

g11545842_3p_a_at

Participates

as a component of

Desmosome:PERP [plasma membrane] (Homo sapiens)

as an input of

PERP binds desmosomes (Homo sapiens)

as an output of

TP53 or TP63 stimulates PERP gene expression (Homo sapiens)

Inferred To

CG6982 [plasma membrane] (Drosophila melanogaster)

PERP [plasma membrane] (Bos taurus)

PERP [plasma membrane] (Canis familiaris)

PERP [plasma membrane] (Danio rerio)

PERP [plasma membrane] (Sus scrofa)

PERP2 [plasma membrane] (Gallus gallus)

Perp [plasma membrane] (Mus musculus)

Perp [plasma membrane] (Rattus norvegicus)

vab-9 [plasma membrane] (Caenorhabditis elegans)

perp [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_071404.2

OpenTargets

ENSG00000112378

GeneCards

Q96FX8

HPA

ENSG00000112378-PERP

Ensembl

ENSG00000112378, ENST00000421351, ENSP00000397157

PRO

Q96FX8

Pharos - Targets

Q96FX8

Orphanet

27930

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:P21145 MAL			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:O95870 ABHGA			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3