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NDUF subunits bind to form the IP subcomplex
Stable Identifier
R-HSA-6800868
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
NDUF subunits bind to form the IP subcomplex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The subunits NDUFS7, S8 and A9, together with NDUFS2 and S3, form an evolutionarily conserved hydrogenase module as part of the Iron-Sulfur protein fraction (IP) subcomplex (Mckenzie & Ryan 2010, Andrews et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
20552642
Assembly factors of human mitochondrial complex I and their defects in disease
Ryan, MT
,
McKenzie, M
IUBMB Life
2010
24191001
Assembly factors for the membrane arm of human complex I
Fearnley, IM
,
Carroll, J
,
Andrews, B
,
Walker, JE
,
Ding, S
Proc. Natl. Acad. Sci. U.S.A.
2013
Participants
Input
NDUFA9:FAD [mitochondrial matrix]
(Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix]
(Homo sapiens)
NDUFS3 [mitochondrial matrix]
(Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix]
(Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Homo sapiens)
Output
IP subcomplex [mitochondrial matrix]
(Homo sapiens)
Participates
as an event of
Complex I biogenesis (Homo sapiens)
Orthologous Events
NDUF subunits bind to form the IP subcomplex (Bos taurus)
NDUF subunits bind to form the IP subcomplex (Caenorhabditis elegans)
NDUF subunits bind to form the IP subcomplex (Canis familiaris)
NDUF subunits bind to form the IP subcomplex (Dictyostelium discoideum)
NDUF subunits bind to form the IP subcomplex (Drosophila melanogaster)
NDUF subunits bind to form the IP subcomplex (Gallus gallus)
NDUF subunits bind to form the IP subcomplex (Mus musculus)
NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)
NDUF subunits bind to form the IP subcomplex (Sus scrofa)
NDUF subunits bind to form the IP subcomplex (Xenopus tropicalis)
Authored
Jassal, B (2015-09-30)
Reviewed
Meldal, BH (2015-10-01)
Created
Jassal, B (2015-09-30)
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