Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ORMDL3 [secretory granule membrane]
Stable Identifier
R-HSA-6800882
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Synonyms
ORM1-like protein 3, ORML3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
ORMDL3 [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N138 ORMDL3
Gene Names
ORMDL3
Chain
chain:1-153
Reference Genes
BioGPS Gene:94103 ORMDL3
COSMIC (genes):ORMDL3 ORMDL3
CTD Gene:94103 ORMDL3
dbSNP Gene:94103 ORMDL3
ENSEMBL:ENSG00000172057 ORMDL3
HGNC:16038 ORMDL3
KEGG:hsa:94103 ORMDL3
Monarch:94103 ORMDL3
NCBI Gene:94103 ORMDL3
OMIM:610075 ORMDL3
UCSC:Q8N138 ORMDL3
Reference Transcript
RefSeq:XM_017025346.1 ORMDL3
RefSeq:NM_001320801.1 ORMDL3
RefSeq:NM_001320803.1 ORMDL3
RefSeq:NM_001320802.1 ORMDL3
RefSeq:NM_139280.3 ORMDL3
RefSeq:XM_017025347.1 ORMDL3
RefSeq:XM_017025348.1 ORMDL3
Other Identifiers
11736188_a_at
11736189_a_at
16844239
223259_PM_at
223259_at
235136_PM_at
235136_at
240701_PM_at
240701_at
3755931
3755933
3755935
3755936
3755937
3755938
3755939
3755940
3755941
3755942
3755943
3755944
3755945
3755946
3755947
3755948
3755949
3755950
3755951
65146_at
78377_at
8014916
94103
A_23_P129829
A_23_P38190
GE54915
GO:0002903
GO:0005515
GO:0005783
GO:0005789
GO:0005886
GO:0006629
GO:0006672
GO:0006686
GO:0006940
GO:0010508
GO:0016020
GO:0017059
GO:0030148
GO:0030667
GO:0035579
GO:0042552
GO:0043226
GO:0044255
GO:0061744
GO:0090153
GO:0090156
GO:1900060
GO:1900182
GO:2000303
HMNXSV003026187
Hs.133167.0.A1_3p_at
Hs.293711.0.A1_3p_at
ILMN_1662174
PH_hs_0022499
PH_hs_0031753
TC17002852.hg
g12653706_3p_at
g12653706_3p_x_at
Participates
as a member of
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
Other forms of this molecule
ORMDL3 [plasma membrane]
ORMDL3 [specific granule membrane]
ORMDL3 [endoplasmic reticulum membrane]
Inferred To
ORM2 [secretory granule membrane]
(Saccharomyces cerevisiae)
ORM1 [secretory granule membrane]
(Saccharomyces cerevisiae)
Homologues of ORMDL3 [secretory granule membrane]
(Saccharomyces cerevisiae)
ormdl3 [secretory granule membrane]
(Danio rerio)
ORMDL [secretory granule membrane]
(Drosophila melanogaster)
ORMDL3 [secretory granule membrane]
(Bos taurus)
ORMDL3 [secretory granule membrane]
(Canis familiaris)
ORMDL3 [secretory granule membrane]
(Dictyostelium discoideum)
ORMDL3 [secretory granule membrane]
(Gallus gallus)
ORMDL3 [secretory granule membrane]
(Schizosaccharomyces pombe)
ORMDL3 [secretory granule membrane]
(Sus scrofa)
Ormdl3 [secretory granule membrane]
(Mus musculus)
Ormdl3 [secretory granule membrane]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000172057
ENSEMBL
ENSP00000464455
,
ENST00000394169
,
ENSP00000377724
,
ENSP00000464693
,
ENST00000584220
,
ENST00000304046
,
ENST00000579695
,
ENSP00000304858
HPA
ENSG00000172057-ORMDL3
PRO
Q8N138
Pharos - Targets
Q8N138
PDB
7YIY
,
6M4O
,
7K0M
,
7K0O
,
7CQI
,
7CQK
,
6M4N
,
7YJ1
,
7K0N
,
7YJ2
,
7K0Q
,
7YIU
,
7K0P
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q14973 SLC10A1
1
SLC10A1 [plasma membrane]
(R-HSA-194116)
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text