Reactome | COPB1 [secretory granule membrane]

COPB1 [secretory granule membrane]

Stable Identifier

R-HSA-6800914

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

Coatomer beta subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P53618 COPB1

Gene Names

COPB1, COPB, MSTP026

Chain

initiator methionine:, chain:2-953

Reference Genes

BioGPS Gene:1315 COPB1

COSMIC (genes):COPB1 COPB1

CTD Gene:1315 COPB1

dbSNP Gene:1315 COPB1

ENSEMBL:ENSG00000129083 COPB1

ENSEMBL_homo_sapiens_GENE:ENSG00000129083.13 COPB1

HGNC:2231 COPB1

KEGG Gene (Homo sapiens):1315 COPB1

Monarch:1315 COPB1

NCBI Gene:1315 COPB1

OMIM:600959 COPB1

UCSC:P53618 COPB1

Reference Transcript

Other Identifiers

11743275_a_at

1315

16736014

201358_PM_s_at

201358_s_at

201359_PM_at

201359_at

3363932

3363933

3363934

3363935

3363937

3363940

3363943

3363944

3363945

3363947

3363949

3363951

3363952

3363954

3363957

3363958

3363959

3363961

3363962

3363963

3363964

3363965

3363966

3363967

3363968

3363971

3363972

3363974

3363975

3363976

34326_at

7946703

A_33_P3287263

GE56656

GO:0000139

GO:0005198

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0005798

GO:0005829

GO:0005886

GO:0006886

GO:0006888

GO:0006891

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030126

GO:0030133

GO:0030137

GO:0030663

GO:0030667

GO:0031410

GO:0043226

GO:0043231

GO:0070821

GO:0101003

HMNXSV003058333

ILMN_1699112

PH_hs_0000384

TC11003473.hg

X82103_at

g7705368_3p_a_at

g7705368_3p_x_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

COPB1 [endoplasmic reticulum membrane]

COPB1 [Golgi membrane]

COPB1 [transport vesicle]

COPB1 [cytosol]

COPB1 [ficolin-1-rich granule membrane]

COPB1 [plasma membrane]

COPB1 [tertiary granule membrane]

Inferred To

copb-1 [secretory granule membrane] (Caenorhabditis elegans)

SEC26 [secretory granule membrane] (Saccharomyces cerevisiae)

betaCOP [secretory granule membrane] (Drosophila melanogaster)

copb [secretory granule membrane] (Dictyostelium discoideum)

Copb1 [secretory granule membrane] (Mus musculus)

Copb1 [secretory granule membrane] (Rattus norvegicus)

sec26 [secretory granule membrane] (Schizosaccharomyces pombe)

COPB1 [secretory granule membrane] (Bos taurus)

COPB1 [secretory granule membrane] (Canis familiaris)

COPB1 [secretory granule membrane] (Gallus gallus)

COPB1 [secretory granule membrane] (Plasmodium falciparum)

COPB1 [secretory granule membrane] (Sus scrofa)

copb1 [secretory granule membrane] (Danio rerio)

copb1 [secretory granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001137534.1, NP_057535.1, NP_001137533.1

OpenTargets

ENSG00000129083

GeneCards

P53618

HPA

ENSG00000129083-COPB1

Ensembl

ENST00000439561, ENSG00000129083, ENST00000249923, ENSP00000397873, ENSP00000249923

PRO

P53618

Pharos - Targets

P53618

HMDB Protein

HMDBP08331

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	13
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	6
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.564	3
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.556	3
UniProt:P60468 SEC61B	3	SEC61B [cytosol] (R-HSA-5250571) SEC61B [endoplasmic reticulum membrane] (R-HSA-264899) SEC61B [phagocytic vesicle membrane] (R-HSA-1236882)	0.527	2

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